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    Cd99l2 CD99 molecule-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171485, updated on 9-Dec-2024

    Summary

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    Symbol
    Cd99l2provided by RGD
    Full Name
    CD99 molecule-like 2provided by RGD
    Primary source
    RGD:620896
    See related
    EnsemblRapid:ENSRNOG00000089435 AllianceGenome:RGD:620896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mic2l1; vms-tm2
    Summary
    Predicted to be involved in cell adhesion. Predicted to act upstream of or within diapedesis; positive regulation of T cell extravasation; and positive regulation of neutrophil extravasation. Predicted to be located in adherens junction and cell surface. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 123.5), Kidney (RPKM 101.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd99l2 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (6861242..6906838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (5265257..5311232)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 14-like Neighboring gene disks large homolog 5-like Neighboring gene disks large homolog 5-like Neighboring gene uncharacterized LOC134481942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of Rhombex-40 a transmembrane protein from the ventral medullary surface of the rat brain by differential display. Shimokawa N, et al. Life Sci, 2000 Apr 21. PMID 10834302
    2. Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. Seelige R, et al. J Immunol, 2013 Feb 1. PMID 23293350
    3. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Suh YH, et al. Gene, 2003 Mar 27. PMID 12706889
    4. A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Bixel MG, et al. Blood, 2007 Jun 15. PMID 17344467
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within diapedesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD99 antigen-like protein 2
    Names
    CD99 antigen-like protein 2-like
    Cd99 antigen-like 2
    MIC2 like 1
    MIC2-like protein 1
    Rhombex-40
    protein rhombex-40
    rhombencephalic expression protein 40 kDa
    single-pass transmembrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409570.2 → NP_001396499.1  CD99 antigen-like protein 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q8R1R5, Q9JJL7
      Related
      ENSRNOP00000112095.1, ENSRNOT00000134845.1

    2. NM_001433497.1 → NP_001420426.1  CD99 antigen-like protein 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q8R1R5, Q9JJL7

    3. NM_001433498.1 → NP_001420427.1  CD99 antigen-like protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    4. NM_001433499.1 → NP_001420428.1  CD99 antigen-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RNA

    1. NR_197405.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      6861242..6906838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273956.1 → XP_063130026.1  CD99 antigen-like protein 2 isoform X2

    2. XM_063273955.1 → XP_063130025.1  CD99 antigen-like protein 2 isoform X1

    3. XM_063273957.1 → XP_063130027.1  CD99 antigen-like protein 2 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134459.1: Suppressed sequence

      Description
      NM_134459.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1R5.1 GenPept UniProtKB/Swiss-Prot:Q8R1R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.