Ocm oncomodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ocmprovided by RGD
Official Full Name: oncomodulinprovided by RGD
Primary source: RGD:3222
See related: EnsemblRapid:ENSRNOG00000001031 AllianceGenome:RGD:3222
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OM; Ocm2
Summary: Enables calcium ion binding activity and protein homodimerization activity. Involved in cochlea development and response to wounding. Located in several cellular components, including cuticular plate; extracellular space; and stereocilium. Part of protein-containing complex. Orthologous to several human genes including OCM2 (oncomodulin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 8.5), Spleen (RPKM 5.9) and 4 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15649452..15710375)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10535619..10596705)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12611121..12634472)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox Sensor.
Title: The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox Sensor.
Leucine 85 is an important determinant of divalent ion affinity in rat beta-parvalbumin
Title: Leucine 85 is an important determinant of divalent ion affinity in rat beta-parvalbumin (Oncomodulin).
Solution structure of Ca2+-free oncomodulin is reported.
Title: Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin).
Oncomodulin expression begins between postnatal day 2 and P4 and peaks as early as P10; it is uniquely expressed by the outer hair cells (OHCs) in the rat cochlea and occurs after efferent innervation along the cochlear spiral between P2 and P4.
Title: Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development.
Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems.
Title: Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells.
Oncomodulin is a growth factor for neurons of the mature central and peripheral nervous systems.
Title: Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cuticular plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in supramolecular fiber	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: oncomodulin

Names: oncmodulin; oncomodulin 2; parvalbumin beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012995.2 → NP_037127.1 oncomodulin

See identical proteins and their annotated locations for NP_037127.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P02631

UniProtKB/TrEMBL

A6K1I3

Related

ENSRNOP00000075788.2, ENSRNOT00000092601.3

Conserved Domains (1) summary

cd16255
Location:9 → 109

EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

15649452..15710375

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271084.1 → XP_063127154.1 oncomodulin isoform X2

UniProtKB/Swiss-Prot

P02631

UniProtKB/TrEMBL

A6K1I3
XM_063271083.1 → XP_063127153.1 oncomodulin isoform X2

UniProtKB/Swiss-Prot

P02631

UniProtKB/TrEMBL

A6K1I3
XM_006248852.4 → XP_006248914.1 oncomodulin isoform X1

Related

ENSRNOP00000110303.1, ENSRNOT00000135538.1

Conserved Domains (2) summary

cd00051
Location:63 → 128

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:64 → 127

EF-hand_7; EF-hand domain pair
XM_063271085.1 → XP_063127155.1 oncomodulin isoform X2

UniProtKB/Swiss-Prot

P02631

UniProtKB/TrEMBL

A6K1I3