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    Adam32 ADAM metallopeptidase domain 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam32provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 32provided by RGD
    Primary source
    RGD:735114
    See related
    EnsemblRapid:ENSRNOG00000025728 AllianceGenome:RGD:735114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; male gonad development; and proteolysis. Predicted to be active in plasma membrane. Orthologous to human ADAM32 (ADAM metallopeptidase domain 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 520.2) See more
    Orthologs
    human all
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    Genomic context

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    See Adam32 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73805023..73914787)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67102384..67212163)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71889035..71999151)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 2 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene U6 spliceosomal RNA Neighboring gene ADAM metallopeptidase domain 5 Neighboring gene ADAM metallopeptidase domain 3A Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 32
    Names
    a disintegrin and metallopeptidase domain 32
    a disintegrin and metalloprotease domain 32
    metalloprotease/disintegrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170582.1 → NP_001164053.1  disintegrin and metalloproteinase domain-containing protein 32 precursor

      Status: VALIDATED

      Source sequence(s)
      AJ131563, CV102424, JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZEP8
      Related
      ENSRNOP00000031189.7, ENSRNOT00000038266.8
      Conserved Domains (5) summary
      smart00608
      Location:482 → 621
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:187 → 381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:399 → 478
      Disintegrin; Disintegrin
      pfam01421
      Location:187 → 383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:46 → 143
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73805023..73914787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094670.2 → XP_038950598.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

      UniProtKB/TrEMBL
      D3ZEP8
      Related
      ENSRNOP00000104032.1, ENSRNOT00000129849.1
      Conserved Domains (4) summary
      smart00608
      Location:496 → 635
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:413 → 491
      Disintegrin
      pfam01421
      Location:201 → 397
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:46 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_001841542.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials