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    Ppil1 peptidylprolyl isomerase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppil1provided by RGD
    Official Full Name
    peptidylprolyl isomerase like 1provided by RGD
    Primary source
    RGD:1309119
    See related
    EnsemblRapid:ENSRNOG00000000523 AllianceGenome:RGD:1309119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable disordered domain specific binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in embryonic brain development; gene expression; and protein peptidyl-prolyl isomerization. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 14. Orthologous to human PPIL1 (peptidylprolyl isomerase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 338.4), Spleen (RPKM 190.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppil1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7303919..7323962, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7302292..7322349, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6515638..6864571, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483865 Neighboring gene copine 5 Neighboring gene uncharacterized LOC102547155 Neighboring gene transfer RNA threonine (anticodon AGU) 18 Neighboring gene similar to human chromosome 6 open reading frame 89 Neighboring gene uncharacterized LOC120098949 Neighboring gene peptidase inhibitor 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR. Wang X, et al. J Biol Chem, 2010 Feb 12. PMID 20007319, Free PMC Article
    2. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. Xu C, et al. J Biol Chem, 2006 Jun 9. PMID 16595688
    3. Spliceosomal immunophilins. Mesa A, et al. FEBS Lett, 2008 Jul 9. PMID 18544344, Free PMC Article
    4. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
    5. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23742842

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116359

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in embryonic brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase-like 1
    Names
    peptidylprolyl isomerase (cyclophilin)-like 1
    NP_001029360.1
    XP_063135217.1
    XP_063135218.1
    XP_063135219.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034188.1 → NP_001029360.1  peptidyl-prolyl cis-trans isomerase-like 1

      See identical proteins and their annotated locations for NP_001029360.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099188
      UniProtKB/TrEMBL
      F7FJ93, Q4KLI4
      Related
      ENSRNOP00000076232.1, ENSRNOT00000093253.3
      Conserved Domains (1) summary
      cd01922
      Location:15 → 161
      cyclophilin_SpCYP2_like; cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent manner indicating ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7303919..7323962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279148.1 → XP_063135218.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

      UniProtKB/TrEMBL
      F7FJ93, Q4KLI4

    2. XM_063279147.1 → XP_063135217.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

      UniProtKB/TrEMBL
      F7FJ93, Q4KLI4

    3. XM_063279149.1 → XP_063135219.1  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1

      UniProtKB/TrEMBL
      F7FJ93, Q4KLI4
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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