Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sugt1provided by RGD
Official Full Name: SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by RGD
Primary source: RGD:1307550
See related: EnsemblRapid:ENSRNOG00000012594 AllianceGenome:RGD:1307550
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aa1114
Summary: Predicted to enable lncRNA binding activity. Predicted to be involved in kinetochore assembly and regulation of protein stability. Predicted to act upstream of or within skeletal muscle satellite cell proliferation and spindle organization. Predicted to be located in cytoplasm and kinetochore. Predicted to be part of protein-containing complex. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 252.8), Heart (RPKM 217.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (61400478..61441303)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (54991419..55032244)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (61873158..61913983)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in kinetochore assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein SGT1 homolog

Names: Suppressor of G2 allele of SKP1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013051.1 → NP_001013069.1 protein SGT1 homolog

See identical proteins and their annotated locations for NP_001013069.1

Status: PROVISIONAL

Source sequence(s)

BC158724

UniProtKB/Swiss-Prot

B0BN85

UniProtKB/TrEMBL

A0A8I6A2D1, A6HU03

Related

ENSRNOP00000085823.2, ENSRNOT00000110035.2

Conserved Domains (5) summary

cd06489
Location:146 → 229

p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...

smart00028
Location:45 → 78

TPR; Tetratricopeptide repeats

PLN03088
Location:21 → 336

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:44 → 74

TPR; TPR repeat [structural motif]

pfam05002
Location:256 → 336

SGS; SGS domain