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    Commd8 COMM domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289603, updated on 9-Dec-2024

    Summary

    Official Symbol
    Commd8provided by RGD
    Official Full Name
    COMM domain containing 8provided by RGD
    Primary source
    RGD:1305402
    See related
    AllianceGenome:RGD:1305402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human COMMD8 (COMM domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 185.0), Brain (RPKM 171.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Commd8 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (36403000..36413577)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (36049040..36059617)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38612408..38622586)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene ATPase phospholipid transporting 10D (putative) Neighboring gene myosin light chain 6, pseudogene 3 Neighboring gene uncharacterized LOC120096598 Neighboring gene gamma-aminobutyric acid type A receptor subunit beta1 Neighboring gene olfactory receptor family 6 subfamily C member 66G, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    COMM domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106004.2NP_001099474.1  COMM domain-containing protein 8

      See identical proteins and their annotated locations for NP_001099474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159414
      UniProtKB/TrEMBL
      A6JD80, B0K015, F7EMP1
      Conserved Domains (1) summary
      cd04756
      Location:7182
      Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      36403000..36413577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091711.2XP_038947639.1  COMM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A6JD81
      Conserved Domains (1) summary
      cl06336
      Location:192
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...