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    Klhl13 kelch-like family member 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl13provided by RGD
    Official Full Name
    kelch-like family member 13provided by RGD
    Primary source
    RGD:1559646
    See related
    EnsemblRapid:ENSRNOG00000014029 AllianceGenome:RGD:1559646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 107.3), Muscle (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl13 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (118747298..118912279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (113942309..114107299, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (121578965..121735014, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Sec61 translocon subunit gamma, pseudogene 4 Neighboring gene ribosomal protein S26, pseudogene 7 Neighboring gene uncharacterized LOC108349247 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120099301

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Sumara I, et al. Dev Cell, 2007 Jun. PMID 17543862
    2. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100854.1 → NP_001094324.1  kelch-like protein 13 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZU85, A0A8I6A140, A6JMD3

    2. NM_001401131.1 → NP_001388060.1  kelch-like protein 13 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AHM2, F1LM44
      Related
      ENSRNOP00000018788.6, ENSRNOT00000018788.10
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    3. NM_001401132.1 → NP_001388061.1  kelch-like protein 13 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZU85, A0A8I6A901
      Related
      ENSRNOP00000090232.1, ENSRNOT00000101919.2

    4. NM_001401133.1 → NP_001388062.1  kelch-like protein 13 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZU85, A0A8I6A140, A6JMD3
      Related
      ENSRNOP00000084359.1, ENSRNOT00000111718.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      118747298..118912279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100612.2 → XP_038956540.1  kelch-like protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHM2, F1LM44
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    2. XM_003752130.6 → XP_003752178.1  kelch-like protein 13 isoform X2

      See identical proteins and their annotated locations for XP_003752178.1

      UniProtKB/TrEMBL
      A0A8I5ZU85, A0A8I6A5N5
      Related
      ENSRNOP00000088723.1, ENSRNOT00000094972.2
      Conserved Domains (6) summary
      smart00612
      Location:445 → 490
      Kelch; Kelch domain
      PHA03098
      Location:94 → 637
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:381 → 429
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:84 → 190
      BTB; BTB/POZ domain
      pfam01344
      Location:380 → 430
      Kelch_1; Kelch motif
      pfam07707
      Location:198 → 299
      BACK; BTB And C-terminal Kelch

    3. XM_063279989.1 → XP_063136059.1  kelch-like protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZU85
      Related
      ENSRNOP00000082058.1, ENSRNOT00000106563.2

    4. XM_006257444.5 → XP_006257506.1  kelch-like protein 13 isoform X3

      See identical proteins and their annotated locations for XP_006257506.1

      UniProtKB/TrEMBL
      A0A8I5ZU85, A0A8I6AB93
      Related
      ENSRNOP00000088688.1, ENSRNOT00000094168.2
      Conserved Domains (6) summary
      smart00612
      Location:442 → 487
      Kelch; Kelch domain
      PHA03098
      Location:91 → 634
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:378 → 426
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:81 → 187
      BTB; BTB/POZ domain
      pfam01344
      Location:377 → 427
      Kelch_1; Kelch motif
      pfam07707
      Location:195 → 296
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein Strain
    Heading Accession and Version

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