Ctc1 CST telomere replication complex component 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctc1provided by RGD
Official Full Name: CST telomere replication complex component 1provided by RGD
Primary source: RGD:1563106
See related: EnsemblRapid:ENSRNOG00000005357 AllianceGenome:RGD:1563106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563106
Summary: Predicted to enable G-rich strand telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase; positive regulation of DNA replication; and telomere maintenance via telomere lengthening. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; hematopoietic stem cell proliferation; and replicative senescence. Predicted to be located in chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of CST complex. Orthologous to human CTC1 (CST telomere replication complex component 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 110.3), Kidney (RPKM 106.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54212537..54234146)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53714614..53735298)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55596172..55616873)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone marrow development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within replicative senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CST complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CST complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CST complex subunit CTC1

Names: CTS telomere maintenance complex component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107010.1 → NP_001100480.1 CST complex subunit CTC1

See identical proteins and their annotated locations for NP_001100480.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I6AE77, A6HFM6

Related

ENSRNOP00000091731.1, ENSRNOT00000117121.2

Conserved Domains (1) summary

pfam15489
Location:61 → 1195

CTC1; CST, telomere maintenance, complex subunit CTC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54212537..54234146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246699.5 → XP_006246761.1 CST complex subunit CTC1 isoform X1

UniProtKB/TrEMBL

A0A8I6AE77, D4A261

Related

ENSRNOP00000007447.7, ENSRNOT00000007447.9

Conserved Domains (1) summary

pfam15489
Location:61 → 1196

CTC1; CST, telomere maintenance, complex subunit CTC1
XM_006246700.3 → XP_006246762.1 CST complex subunit CTC1 isoform X2

UniProtKB/TrEMBL

A0A8I6AE77

Conserved Domains (1) summary

pfam15489
Location:1 → 960

CTC1; CST, telomere maintenance, complex subunit CTC1