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    Creg1 cellular repressor of E1A-stimulated genes 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Creg1provided by RGD
    Official Full Name
    cellular repressor of E1A-stimulated genes 1provided by RGD
    Primary source
    RGD:1306804
    See related
    AllianceGenome:RGD:1306804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Creg
    Summary
    Predicted to act upstream of or within several processes, including autophagy; lysosomal lumen acidification; and regulation of DNA-templated transcription. Predicted to be located in endosome and lysosome. Predicted to be part of transcription regulator complex. Predicted to be active in extracellular space. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 504.6), Spleen (RPKM 329.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Creg1 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80552779..80565272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78019814..78032310)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83972186..83984675)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096304 Neighboring gene uncharacterized LOC120096305 Neighboring gene Cd247 molecule Neighboring gene POU class 2 homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats. Tai TT, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33215442
    2. Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats. Liu ML, et al. Am J Nephrol, 2020. PMID 32320986
    3. Antiapoptotic role of the cellular repressor of E1A-stimulated genes (CREG) in retinal photoreceptor cells in a rat model of light-induced retinal injury. Zhang TZ, et al. Biomed Pharmacother, 2018 Jul. PMID 29864918
    4. Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-α-induced apoptosis via NF-κB in mesenchymal stem cells. Peng CF, et al. Biochem Biophys Res Commun, 2011 Mar 25. PMID 21354106
    5. Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II. Li Y, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28062494

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
      Title: CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
    2. Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
      Title: Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
    3. CREG protected retinal cells against apoptosis by inhibiting P38/MAPK and JNK/MAPK signaling pathways and activating the PI3K-AKT signaling pathway.
      Title: Antiapoptotic role of the cellular repressor of E1A-stimulated genes (CREG) in retinal photoreceptor cells in a rat model of light-induced retinal injury.
    4. CREG is a novel mediator of vascular remodeling in response to Ang II.
      Title: Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
    5. The results of this study indicate that CREG acts as a novel and potent survival factor in mesenchymal stem cells.
      Title: Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-α-induced apoptosis via NF-κB in mesenchymal stem cells.
    6. This study indicates that CREG is a novel and potent survival factor for mesenchymal stem cells.
      Title: Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt.
    7. CREG was found to inhibit cardiac cell growth as a novel regulator of ERK1/2 and might participate in the development of cardiac hypertrophy under pressure overload
      Title: CREG, a new regulator of ERK1/2 in cardiac hypertrophy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CREG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105966.1 → NP_001099436.1  protein CREG1 precursor

      See identical proteins and their annotated locations for NP_001099436.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      B2GUX7, F7FH64
      Conserved Domains (1) summary
      pfam13883
      Location:50 → 216
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80552779..80565272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769625.4 → XP_008767847.2  protein CREG1 isoform X1

      UniProtKB/TrEMBL
      B2GUX7, F7FH64
      Conserved Domains (1) summary
      pfam13883
      Location:50 → 216
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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