Clic1 chloride intracellular channel 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Clic1provided by RGD
Full Name: chloride intracellular channel 1provided by RGD
Primary source: RGD:1303043
See related: EnsemblRapid:ENSRNOG00000029682 AllianceGenome:RGD:1303043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chloride channel activity. Predicted to be involved in chloride transport and platelet aggregation. Predicted to act upstream of or within positive regulation of osteoblast differentiation and regulation of mitochondrial membrane potential. Located in mitochondrial membrane. Orthologous to human CLIC1 (chloride intracellular channel 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 447.5), Thymus (RPKM 429.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3769522..3778367, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3764867..3773711, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5040314..5049166)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria.
Title: Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
examined the effect of pharmacological blockade of CLIC1 in protecting cortical neurons from toxicity caused by Abeta1-42- and lipopolysaccaride-stimulated microglia
Title: Intracellular ion channel CLIC1: involvement in microglia-mediated β-amyloid peptide(1-42) neurotoxicity.
CLIC1 may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors, although its physiologic role in osteoblasts remains to be determined.
Title: Chloride intracellular channel 1 regulates osteoblast differentiation.
These results provide a direct link between Abeta-induced microglial activation and CLIC1 functional expression.
Title: Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity.

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General gene information

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Markers

Aif1 (e-PCR), detects polymorphism
- UniSTS:141056

RH137048 (e-PCR)
- UniSTS:219137

Tnf (e-PCR), detects polymorphism
- UniSTS:144645

Tnf (e-PCR), detects polymorphism
- UniSTS:144649

RH129972 (e-PCR)
- UniSTS:213260

AI177560 (e-PCR)
- UniSTS:250387

MARC_5857-5858:997299374:1 (e-PCR)
- UniSTS:269591

D20Yum51 (e-PCR)
- UniSTS:526106

RH135373 (e-PCR)
- UniSTS:218650

MARC_11957-11958:1003854518:1 (e-PCR)
- UniSTS:267292

RH127662 (e-PCR)
- UniSTS:210972

Bat1_microsatellite (e-PCR)
- UniSTS:240926

RH142043 (e-PCR)
- UniSTS:224033

D20Yum50 (e-PCR)
- UniSTS:526121

D20Ztm1 (e-PCR)
- UniSTS:517939

RH139920 (e-PCR)
- UniSTS:222004

RH138896 (e-PCR)
- UniSTS:220983

D20Yum47 (e-PCR)
- UniSTS:526137

D20Yum49 (e-PCR)
- UniSTS:526142

D20Wox4 (e-PCR)
- UniSTS:118079

D20Yum48 (e-PCR)
- UniSTS:526148

D20Yum52 (e-PCR)
- UniSTS:526149

RH138655 (e-PCR)
- UniSTS:220742

BE098892 (e-PCR)
- UniSTS:245318

UniSTS:498506 (e-PCR)
- UniSTS:498506

Ly6g6e (e-PCR), detects polymorphism
- UniSTS:498506

UniSTS:463959 (e-PCR)
- UniSTS:463959

Tnf (e-PCR), detects polymorphism
- UniSTS:463959

RH132872 (e-PCR)
- UniSTS:216155

RH126881 (e-PCR)
- UniSTS:209757

MARC_3347-3348:966881404:1 (e-PCR)
- UniSTS:231017

MARC_3347-3348:991937077:1 (e-PCR)
- UniSTS:231017

RH144334 (e-PCR)
- UniSTS:233579

BQ194350 (e-PCR)
- UniSTS:261739

AA997909 (e-PCR)
- UniSTS:248428

D20UW1 (e-PCR), detects polymorphism
- UniSTS:118647

RH132137 (e-PCR)
- UniSTS:215420

D20Wox23 (e-PCR)
- UniSTS:518782

MARC_5045-5046:996690083:1 (e-PCR)
- UniSTS:269443

PMC112151P1 (e-PCR)
- UniSTS:270227

RH126866 (e-PCR)
- UniSTS:209300

RH35871 (e-PCR)
- UniSTS:42137

D20Wox3 (e-PCR)
- UniSTS:240026

RH133704 (e-PCR)
- UniSTS:216987

RH94729 (e-PCR)
- UniSTS:119976

RH94730 (e-PCR)
- UniSTS:119977

AI113237 (e-PCR)
- UniSTS:245936

MARC_5411-5412:996690356:1 (e-PCR)
- UniSTS:269505

RH128085 (e-PCR)
- UniSTS:211393

RH143921 (e-PCR)
- UniSTS:233167

D20Mgh3 (e-PCR)
- UniSTS:227288

PMC26794P3 (e-PCR)
- UniSTS:272353

RH135060 (e-PCR)
- UniSTS:218337

Clic1 (e-PCR), detects polymorphism
- UniSTS:499174

PMC116546P1 (e-PCR)
- UniSTS:270314

AA900379 (e-PCR)
- UniSTS:248821

RH94817 (e-PCR)
- UniSTS:120063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated chloride channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	TAS Traceable Author Statement more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	TAS Traceable Author Statement more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride intracellular channel protein 1

Names: glutaredoxin-like oxidoreductase CLIC1; glutathione-dependent dehydroascorbate reductase CLIC1

NP_001002807.1

EC 1.8.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.