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    Etfbkmt electron transfer flavoprotein subunit beta lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Etfbkmtprovided by RGD
    Official Full Name
    electron transfer flavoprotein subunit beta lysine methyltransferaseprovided by RGD
    Primary source
    RGD:735147
    See related
    EnsemblRapid:ENSRNOG00000036918 AllianceGenome:RGD:735147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mettl20; ETFB-KMT
    Summary
    Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase and peptidyl-lysine trimethylation. Predicted to be located in mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial matrix. Orthologous to human ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 121.0), Spleen (RPKM 105.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etfbkmt in Genome Data Viewer
    Location:
    4q44
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183871819..183936843)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (182140492..182204635)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183655968..183665757)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene U6 spliceosomal RNA Neighboring gene mesoderm specific transcript, pseudogene 1 Neighboring gene antagonist of mitotic exit network 1 homolog Neighboring gene adenosylhomocysteinase-like Neighboring gene basic transcription factor 3, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. Rhein VF, et al. J Biol Chem, 2014 Aug 29. PMID 25023281, Free PMC Article
    2. Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Małecki J, et al. J Biol Chem, 2015 Jan 2. PMID 25416781, Free PMC Article
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72974

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein beta subunit lysine methyltransferase
    Names
    ETFB lysine methyltransferase
    methyltransferase like 20
    methyltransferase-like protein 20
    protein N-lysine methyltransferase METTL20
    NP_942067.1
    XP_006237763.1
    XP_038963650.1
    XP_038963652.1
    XP_038963653.1
    XP_063142266.1
    XP_063142267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198772.2 → NP_942067.1  electron transfer flavoprotein beta subunit lysine methyltransferase

      See identical proteins and their annotated locations for NP_942067.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6P7Q0
      Related
      ENSRNOP00000052309.2, ENSRNOT00000055442.4
      Conserved Domains (1) summary
      cl17173
      Location:58 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      183871819..183936843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107724.2 → XP_038963652.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:58 → 158
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_039107725.2 → XP_038963653.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:58 → 168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_039107722.2 → XP_038963650.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q6P7Q0
      Conserved Domains (1) summary
      cl17173
      Location:58 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_063286197.1 → XP_063142267.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X4

    5. XM_063286196.1 → XP_063142266.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

    6. XM_006237701.5 → XP_006237763.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006237763.1

      UniProtKB/Swiss-Prot
      Q6P7Q0
      Conserved Domains (1) summary
      cl17173
      Location:58 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7Q0.1 GenPept UniProtKB/Swiss-Prot:Q6P7Q0

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