Ly6g6e lymphocyte antigen 6 family member G6E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ly6g6eprovided by RGD
Official Full Name: lymphocyte antigen 6 family member G6Eprovided by RGD
Primary source: RGD:1303112
See related: EnsemblRapid:ENSRNOG00000027157 AllianceGenome:RGD:1303112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acetylcholine receptor activator activity and acetylcholine receptor binding activity. Predicted to be involved in acetylcholine receptor signaling pathway and desensitization of G protein-coupled receptor signaling pathway. Predicted to be located in synapse. Predicted to be active in plasma membrane. Orthologous to human LY6G6E (lymphocyte antigen 6 family member G6E (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 46.0), Kidney (RPKM 20.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3749352..3752578, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3744999..3749867, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5063148..5069032)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

UniSTS:498506 (e-PCR)
- UniSTS:498506

Ly6g6e (e-PCR), detects polymorphism
- UniSTS:498506

RH135060 (e-PCR)
- UniSTS:218337

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor activator activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte antigen 6 complex G6E

Names: lymphocyte antigen 6 complex, locus G6E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001972.1 → NP_001001972.1 lymphocyte antigen 6 complex G6E precursor

See identical proteins and their annotated locations for NP_001001972.1

Status: VALIDATED

Source sequence(s)

BX883045

UniProtKB/TrEMBL

A0A1L6ZA28, A0A1L6ZA33, A6KTS9, Q6MG57

Related

ENSRNOP00000032019.4, ENSRNOT00000037482.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3749352..3752578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098955.2 → XP_038954883.1 lymphocyte antigen 6 complex G6E isoform X2

UniProtKB/TrEMBL

A0A1L6ZA28, F7FAA3

Conserved Domains (1) summary

pfam01064
Location:57 → 121

Activin_recp; Activin types I and II receptor domain
XM_039098953.2 → XP_038954881.1 lymphocyte antigen 6 complex G6E isoform X1

UniProtKB/TrEMBL

A0A1L6ZA28