Adgra3 adhesion G protein-coupled receptor A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgra3provided by RGD
Official Full Name: adhesion G protein-coupled receptor A3provided by RGD
Primary source: RGD:1304914
See related: EnsemblRapid:ENSRNOG00000004279 AllianceGenome:RGD:1304914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr125
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in external side of plasma membrane. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 170.7), Kidney (RPKM 163.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (65085418..65188949)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (60874719..60976341)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (64686677..64786813)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU049732 (e-PCR)
- UniSTS:146178

RH140456 (e-PCR)
- UniSTS:222530

RH134656 (e-PCR)
- UniSTS:217935

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable G-protein coupled receptor 125; adhesion G protein-coupled receptor A3

Names: G protein-coupled receptor 125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432811.1 → NP_001419740.1 probable G-protein coupled receptor 125 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2JSU2, A6IJJ3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

65085418..65188949

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092758.2 → XP_038948686.1 adhesion G protein-coupled receptor A3

Related

ENSRNOP00000037291.7, ENSRNOT00000036646.8

Conserved Domains (7) summary

TIGR00864
Location:121 → 226

PCC; polycystin cation channel protein

sd00031
Location:69 → 92

LRR_1; leucine-rich repeat [structural motif]

cd15999
Location:742 → 1049

7tmB2_GPR125; G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam01825
Location:685 → 729

GPS; GPCR proteolysis site, GPS, motif

pfam02793
Location:349 → 402

HRM; Hormone receptor domain

pfam13855
Location:71 → 127

LRR_8; Leucine rich repeat

pfam13927
Location:228 → 310

Ig_3; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107218.1: Suppressed sequence

Description

NM_001107218.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: GPR125 (GeneID:166647).