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    Cep63 centrosomal protein 63 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300963, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cep63provided by RGD
    Official Full Name
    centrosomal protein 63provided by RGD
    Primary source
    RGD:1561183
    See related
    EnsemblRapid:ENSRNOG00000008410 AllianceGenome:RGD:1561183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; non-membrane-bounded organelle assembly; and protein stabilization. Predicted to act upstream of or within several processes, including centrosome duplication; meiosis I; and negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole. Human ortholog(s) of this gene implicated in Seckel syndrome 6. Orthologous to human CEP63 (centrosomal protein 63). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 178.4), Thymus (RPKM 61.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cep63 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112041586..112093061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103162639..103214177, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111063988..111116014, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kyphoscoliosis peptidase Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene uncharacterized LOC134480096 Neighboring gene angiomotin like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC114577

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within meiotic telomere clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction in response to DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 63 kDa
    Names
    centrosomal protein 63kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037772.1NP_001032861.2  centrosomal protein of 63 kDa isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      BC098948
      UniProtKB/TrEMBL
      A0A096MIU4, A6I2H5
      Conserved Domains (1) summary
      pfam17045
      Location:56318
      CEP63; Centrosomal protein of 63 kDa
    2. NM_001244805.1NP_001231734.1  centrosomal protein of 63 kDa isoform 2

      See identical proteins and their annotated locations for NP_001231734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC161815
      UniProtKB/Swiss-Prot
      Q4KLY0
      UniProtKB/TrEMBL
      A6I2H5
      Related
      ENSRNOP00000092635.1, ENSRNOT00000114079.2
      Conserved Domains (1) summary
      pfam17045
      Location:18280
      CEP63; Centrosomal protein of 63 kDa

    RNA

    1. NR_045200.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC083632

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112041586..112093061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081193.2XP_038937121.1  centrosomal protein of 63 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXF3
      Conserved Domains (2) summary
      pfam15921
      Location:29612
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:47309
      CEP63; Centrosomal protein of 63 kDa
    2. XM_017595591.3XP_017451080.2  centrosomal protein of 63 kDa isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:3397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:1189
      CEP63; Centrosomal protein of 63 kDa
    3. XM_039081195.2XP_038937123.1  centrosomal protein of 63 kDa isoform X2

      Conserved Domains (2) summary
      pfam15921
      Location:1583
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:18280
      CEP63; Centrosomal protein of 63 kDa
    4. XM_039081196.2XP_038937124.1  centrosomal protein of 63 kDa isoform X2

      Conserved Domains (2) summary
      pfam15921
      Location:1583
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:18280
      CEP63; Centrosomal protein of 63 kDa
    5. XM_039081191.2XP_038937119.1  centrosomal protein of 63 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXF3
      Related
      ENSRNOP00000070249.3, ENSRNOT00000084413.3
      Conserved Domains (2) summary
      pfam15921
      Location:29612
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:47309
      CEP63; Centrosomal protein of 63 kDa
    6. XM_039081199.2XP_038937127.1  centrosomal protein of 63 kDa isoform X4

      UniProtKB/TrEMBL
      A6I2H5
      Related
      ENSRNOP00000029550.6, ENSRNOT00000031313.8
      Conserved Domains (2) summary
      TIGR02168
      Location:165492
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17045
      Location:47309
      CEP63; Centrosomal protein of 63 kDa
    7. XM_063265227.1XP_063121297.1  centrosomal protein of 63 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXF3
      Related
      ENSRNOP00000083027.2, ENSRNOT00000099786.2
    8. XM_063265229.1XP_063121299.1  centrosomal protein of 63 kDa isoform X5