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    Ifit2 interferon-induced protein with tetratricopeptide repeats 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifit2provided by RGD
    Official Full Name
    interferon-induced protein with tetratricopeptide repeats 2provided by RGD
    Primary source
    RGD:1307804
    See related
    EnsemblRapid:ENSRNOG00000036604 AllianceGenome:RGD:1307804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in defense response to virus and positive regulation of apoptotic process. Predicted to act upstream of or within antiviral innate immune response and cellular response to interferon-alpha. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human IFIT2 (interferon induced protein with tetratricopeptide repeats 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 87.7), Lung (RPKM 87.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ifit2 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241515735..241521799)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232102570..232108638)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252894663..252900727)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cholesterol 25-hydroxylase Neighboring gene lipase A, lysosomal acid type Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The interferon stimulated gene 54 promotes apoptosis. Stawowczyk M, et al. J Biol Chem, 2011 Mar 4. PMID 21190939, Free PMC Article
    2. Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Bluyssen HA, et al. Genomics, 1994 Nov 1. PMID 7896268
    3. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
    4. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Daffis S, et al. Nature, 2010 Nov 18. PMID 21085181, Free PMC Article
    5. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Li Y, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416887, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024753.1 → NP_001019924.1  interferon-induced protein with tetratricopeptide repeats 2

      See identical proteins and their annotated locations for NP_001019924.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097384
      UniProtKB/TrEMBL
      A6I135, Q4V8H9
      Related
      ENSRNOP00000110747.1, ENSRNOT00000172900.1
      Conserved Domains (2) summary
      sd00006
      Location:242 → 270
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51 → 126
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241515735..241521799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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