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    Rbsn rabenosyn, RAB effector [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312562, updated on 9-Dec-2024

    Summary

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    Symbol
    Rbsnprovided by RGD
    Full Name
    rabenosyn, RAB effectorprovided by RGD
    Primary source
    RGD:1305397
    See related
    EnsemblRapid:ENSRNOG00000011391 AllianceGenome:RGD:1305397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfyve20
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport; early endosome to Golgi transport; and regulation of Golgi organization. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 83.0), Brain (RPKM 82.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbsn in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126239354..126269702, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124682228..124712578, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124050559..124080919, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene uncharacterized LOC103692187 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene uncharacterized LOC134486818 Neighboring gene thyrotropin releasing hormone Neighboring gene prickle planar cell polarity protein 2 Neighboring gene uncharacterized LOC134486613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology. Naslavsky N, et al. J Cell Sci, 2009 Feb 1. PMID 19139087, Free PMC Article
    2. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Mishra A, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534488, Free PMC Article
    3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rabenosyn-5
    Names
    zinc finger, FYVE domain containing 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107875.1 → NP_001101345.1  rabenosyn-5

      See identical proteins and their annotated locations for NP_001101345.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IBC3, D3ZL11
      Related
      ENSRNOP00000015602.3, ENSRNOT00000015602.6
      Conserved Domains (3) summary
      cd15716
      Location:150 → 261
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:460 → 498
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:548 → 726
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      126239354..126269702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107619.2 → XP_038963547.1  rabenosyn-5 isoform X4

      Conserved Domains (3) summary
      cd15716
      Location:62 → 173
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:372 → 410
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:460 → 638
      NPF; Rabosyn-5 repeating NPF sequence-motif

    2. XM_039107618.2 → XP_038963546.1  rabenosyn-5 isoform X1

      Conserved Domains (3) summary
      cd15716
      Location:148 → 259
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:458 → 496
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:546 → 724
      NPF; Rabosyn-5 repeating NPF sequence-motif

    3. XM_063286076.1 → XP_063142146.1  rabenosyn-5 isoform X3

    4. XM_006236908.5 → XP_006236970.1  rabenosyn-5 isoform X2

      Conserved Domains (3) summary
      cd15716
      Location:120 → 231
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:427 → 466
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:518 → 696
      NPF; Rabosyn-5 repeating NPF sequence-motif
    Nucleotide Protein Strain
    Heading Accession and Version

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