Ntn5 netrin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntn5provided by RGD
Official Full Name: netrin 5provided by RGD
Primary source: RGD:1565197
See related: EnsemblRapid:ENSRNOG00000021016 AllianceGenome:RGD:1565197
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565197
Summary: Predicted to be involved in neurogenesis. Predicted to be located in extracellular region. Orthologous to human NTN5 (netrin 5). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in Testes (RPKM 17.5), Adrenal (RPKM 4.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105293408..105302163)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96156948..96165997)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101668354..101678117)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin-5

Names: netrin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173526.2 → NP_001166997.1 netrin-5 isoform 2 precursor

Status: INFERRED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

D3ZT86

Related

ENSRNOP00000028524.7, ENSRNOT00000028524.8

Conserved Domains (3) summary

cd00055
Location:227 → 276

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:313 → 442

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

cl02806
Location:80 → 123

Laminin_N; Laminin N-terminal (Domain VI)
NM_001415884.1 → NP_001402813.1 netrin-5 isoform 1 precursor

Status: INFERRED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000096155.2, ENSRNOT00000115935.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105293408..105302163

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589144.3 → XP_017444633.2 netrin-5 isoform X1

Conserved Domains (3) summary

cd00055
Location:287 → 336

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:373 → 502

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

cl02806
Location:77 → 120

Laminin_N; Laminin N-terminal (Domain VI)