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    Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrig3provided by RGD
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 3provided by RGD
    Primary source
    RGD:1561255
    See related
    EnsemblRapid:ENSRNOG00000007654 AllianceGenome:RGD:1561255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561255
    Summary
    Predicted to act upstream of or within otolith morphogenesis. Orthologous to human LRIG3 (leucine rich repeats and immunoglobulin like domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 61.4), Kidney (RPKM 58.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrig3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (63701724..63751898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (61816313..61866275)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (69213098..69263251)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552186 Neighboring gene solute carrier family 16 member 7 Neighboring gene uncharacterized LOC102552637 Neighboring gene uncharacterized LOC102552423 Neighboring gene uncharacterized LOC120093626 Neighboring gene uncharacterized LOC134479599

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression. Yang K, et al. J Cell Biochem, 2019 Oct. PMID 31119777
    2. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article
    3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression.
      Title: Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188535

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within otolith morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432458.1 → NP_001419387.1  leucine-rich repeats and immunoglobulin-like domains protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HQQ1, B5DEJ0, G3V8Y2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      63701724..63751898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_216905.11 → XP_216905.5  leucine-rich repeats and immunoglobulin-like domains protein 3

      Related
      ENSRNOP00000030604.5, ENSRNOT00000032786.7
      Conserved Domains (9) summary
      TIGR00864
      Location:416 → 494
      PCC; polycystin cation channel protein
      COG4886
      Location:77 → 337
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:76 → 99
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:147 → 168
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:697 → 784
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:498 → 585
      Ig_3; Immunoglobulin domain
      cd00096
      Location:705 → 708
      Ig; Ig strand A' [structural motif]
      cd05763
      Location:604 → 694
      IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
      cd21340
      Location:268 → 442
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version

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    Other Literature Sources
    Chemical Information
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    Research Materials