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    Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qtrt1provided by RGD
    Official Full Name
    queuine tRNA-ribosyltransferase catalytic subunit 1provided by RGD
    Primary source
    RGD:620996
    See related
    AllianceGenome:RGD:620996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tgt; Tgut
    Summary
    Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA-guanosine(34) queuine transglycosylase activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be located in mitochondrion and nucleus. Predicted to be part of tRNA-guanine transglycosylase complex. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 32.8), Spleen (RPKM 24.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qtrt1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28239993..28249983)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19965801..19973843)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22447057..22454328)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 44 member 2 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146 Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transfer ribonucleic acid guanine transglycosylase isolated from rat liver. Shindo-Okada N, et al. Biochemistry, 1980 Jan 22. PMID 6986171
    2. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. Chen YC, et al. RNA, 2010 May. PMID 20354154, Free PMC Article
    3. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-guanine transglycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA-guanine transglycosylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-guanine transglycosylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    queuine tRNA-ribosyltransferase catalytic subunit 1
    Names
    guanine insertion enzyme
    queuine tRNA-ribosyltransferase 1
    tRNA-guanine transglycosylase
    NP_071586.2
    XP_038937997.1
    XP_038937998.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022250.2 → NP_071586.2  queuine tRNA-ribosyltransferase catalytic subunit 1

      See identical proteins and their annotated locations for NP_071586.2

      Status: VALIDATED

      Source sequence(s)
      BC097321
      UniProtKB/Swiss-Prot
      Q4QR99, Q9JMA0
      UniProtKB/TrEMBL
      A0A0H2UHF3
      Conserved Domains (1) summary
      pfam01702
      Location:26 → 381
      TGT; Queuine tRNA-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28239993..28249983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082069.2 → XP_038937997.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHF3
      Conserved Domains (1) summary
      pfam01702
      Location:42 → 422
      TGT; Queuine tRNA-ribosyltransferase

    2. XM_039082070.2 → XP_038937998.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X2

      Conserved Domains (1) summary
      pfam01702
      Location:1 → 286
      TGT; Queuine tRNA-ribosyltransferase

    RNA

    1. XR_005487914.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QR99.1 GenPept UniProtKB/Swiss-Prot:Q4QR99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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