Shfl shiftless antiviral inhibitor of ribosomal frameshifting [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shflprovided by RGD
Official Full Name: shiftless antiviral inhibitor of ribosomal frameshiftingprovided by RGD
Primary source: RGD:1565995
See related: EnsemblRapid:ENSRNOG00000020580 AllianceGenome:RGD:1565995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RyDEN
Summary: Predicted to enable identical protein binding activity; ribosome binding activity; and sequence-specific mRNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of translation; and viral translational frameshifting. Predicted to be located in P-body; cytosol; and nucleoplasm. Orthologous to human SHFL (shiftless antiviral inhibitor of ribosomal frameshifting). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 126.9), Brain (RPKM 74.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27683560..27690269)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19408298..19414084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (21890214..21896045)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific mRNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translational frameshifting	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational frameshifting	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational frameshifting	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational termination	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational termination	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interferon-beta	IEA Inferred from Electronic Annotation more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type I interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type III interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type III interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type III interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info
involved_in viral translational frameshifting	ISO Inferred from Sequence Orthology more info
involved_in viral translational frameshifting	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: shiftless antiviral inhibitor of ribosomal frameshifting protein homolog

Names: UPF0515 protein C19orf66 homolog; repressor of yield of DENV protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394375.1 → NP_001381304.1 shiftless antiviral inhibitor of ribosomal frameshifting protein homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AM91, A6JNL7

Related

ENSRNOP00000093661.1, ENSRNOT00000110950.2

Conserved Domains (1) summary

pfam15135
Location:16 → 259

UPF0515; Uncharacterized protein UPF0515

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

27683560..27690269

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081925.2 → XP_038937853.1 shiftless antiviral inhibitor of ribosomal frameshifting protein homolog isoform X1

Conserved Domains (2) summary

PHA03247
Location:164 → 292

PHA03247; large tegument protein UL36; Provisional

pfam15135
Location:16 → 173

UPF0515; Uncharacterized protein UPF0515
XM_008765978.4 → XP_008764200.1 shiftless antiviral inhibitor of ribosomal frameshifting protein homolog isoform X2

UniProtKB/TrEMBL

A0A140TAE2

Related

ENSRNOP00000027949.7, ENSRNOT00000027949.8

Conserved Domains (1) summary

pfam15135
Location:16 → 173

UPF0515; uncharacterized protein UPF0515
XM_039081926.2 → XP_038937854.1 shiftless antiviral inhibitor of ribosomal frameshifting protein homolog isoform X3

UniProtKB/TrEMBL

A0A8I6AT40

Related

ENSRNOP00000097519.1, ENSRNOT00000117855.2

Conserved Domains (1) summary

pfam15135
Location:16 → 215

UPF0515; Uncharacterized protein UPF0515

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025054.1: Suppressed sequence

Description

NM_001025054.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.