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    Msh5 mutS homolog 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msh5provided by RGD
    Official Full Name
    mutS homolog 5provided by RGD
    Primary source
    RGD:1303008
    See related
    EnsemblRapid:ENSRNOG00000000857 AllianceGenome:RGD:1303008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in chiasma assembly. Predicted to act upstream of or within female gamete generation and homologous chromosome pairing at meiosis. Predicted to be located in synaptonemal complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Orthologous to human MSH5 (mutS homolog 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 14.8), Testes (RPKM 13.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msh5 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3779180..3797996)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3773867..3793337)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5020690..5037125, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DDAH family member 2, ADMA-independent Neighboring gene chloride intracellular channel 1 Neighboring gene U6 spliceosomal RNA Neighboring gene suppressor APC domain containing 1 Neighboring gene von Willebrand factor A domain containing 7 Neighboring gene valyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Urinary fistula from segmental infarction in a transplanted kidney: recovery following surgical repair. Fox M, et al. Br J Urol, 1972 Jun. PMID 4557077
    2. Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients. Liu JY, et al. Chin J Cancer, 2017 Jan 16. PMID 28093084, Free PMC Article
    3. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Di Giacomo M, et al. Proc Natl Acad Sci U S A, 2005 Jan 18. PMID 15640358, Free PMC Article
    4. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Kolas NK, et al. Cytogenet Genome Res, 2004. PMID 15467367
    5. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Kolas NK, et al. J Cell Biol, 2005 Nov 7. PMID 16260499, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chiasma assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within female gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mutS protein homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212536.2 → NP_997701.2  mutS protein homolog 5

      See identical proteins and their annotated locations for NP_997701.2

      Status: VALIDATED

      Source sequence(s)
      BC083904
      UniProtKB/TrEMBL
      A0A0H2UI03
      Conserved Domains (5) summary
      cd03281
      Location:553 → 759
      ABC_MSH5_euk; ATP-binding cassette domain of eukaryotic MutS5 homolog
      smart00533
      Location:250 → 565
      MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
      pfam05192
      Location:250 → 379
      MutS_III; MutS domain III
      pfam11369
      Location:63 → 147
      DUF3160; Protein of unknown function (DUF3160)
      cl17822
      Location:394 → 492
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3779180..3797996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279008.1 → XP_063135078.1  mutS protein homolog 5 isoform X4

    2. XM_063279006.1 → XP_063135076.1  mutS protein homolog 5 isoform X2

    3. XM_063279004.1 → XP_063135074.1  mutS protein homolog 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5XHZ5, Q6MG62
      UniProtKB/TrEMBL
      A6KTR1
      Related
      ENSRNOP00000057489.3, ENSRNOT00000060762.4

    4. XM_063279005.1 → XP_063135075.1  mutS protein homolog 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5XHZ5, Q6MG62
      UniProtKB/TrEMBL
      A6KTR1
      Related
      ENSRNOP00000103178.1, ENSRNOT00000150784.1

    5. XM_063279011.1 → XP_063135081.1  mutS protein homolog 5 isoform X7

    6. XM_063279007.1 → XP_063135077.1  mutS protein homolog 5 isoform X3

    7. XM_063279009.1 → XP_063135079.1  mutS protein homolog 5 isoform X5

    8. XM_063279010.1 → XP_063135080.1  mutS protein homolog 5 isoform X6

    RNA

    1. XR_010060634.1 RNA Sequence

    2. XR_010060633.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG62.1 GenPept UniProtKB/Swiss-Prot:Q6MG62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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