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    Slc14a1 solute carrier family 14 member 1 (Kidd blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc14a1provided by RGD
    Official Full Name
    solute carrier family 14 member 1 (Kidd blood group)provided by RGD
    Primary source
    RGD:3688
    See related
    EnsemblRapid:ENSRNOG00000016753 AllianceGenome:RGD:3688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UT3; UT-B; UTB1; UrT2; HUT11
    Summary
    Enables urea transmembrane transporter activity. Involved in urea transport. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 75.8), Spleen (RPKM 72.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc14a1 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73840568..73883925, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (71565453..71608807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (74461064..74504475, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene sialic acid binding Ig-like lectin 15 Neighboring gene uncharacterized LOC102553274 Neighboring gene solute carrier family 14 member 2 Neighboring gene uncharacterized LOC102553338 Neighboring gene uncharacterized LOC134483059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin. Song W, et al. Med Sci Monit, 2015 Sep 28. PMID 26414230, Free PMC Article
    2. High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats. Guo L, et al. Biochem Biophys Res Commun, 2015 May 29. PMID 25869070, Free PMC Article
    3. Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues. Timmer RT, et al. Am J Physiol Cell Physiol, 2001 Oct. PMID 11546670
    4. Cloning and functional characterization of a rat urea transporter: expression in the brain. Couriaud C, et al. Biochim Biophys Acta, 1996 Dec 11. PMID 8982255
    5. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Esteva-Font C, et al. Biochim Biophys Acta, 2015 May. PMID 25613743, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Urea Transporter Protein is abnormally expressed in a rat model of hepatorenal syndrome induced by succinylated gelatin
      Title: Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
    2. Report thiourea analogs as inhibitors of UT-B mediated urea transport.
      Title: Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
    3. UT-B expression in the choroid plexus was reduced by high salt diet.
      Title: High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats.
    4. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity.
      Title: A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic.
    5. Changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.
      Title: Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.
    6. expression of urea transporters in short-loop DTL and DVR coincides with the development of the ability to produce a concentrated urine.
      Title: Expression of urea transporters in the developing rat kidney.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables urea channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urea channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urea channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables urea transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables urea transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urea transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables water transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urea transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urea transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in urea transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within urea transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in water transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within water transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    urea transporter 1
    Names
    solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
    urea transporter B
    urea transporter, erythrocyte

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019346.3 → NP_062219.3  urea transporter 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      E9PSP0, P70633, P97689
      UniProtKB/TrEMBL
      A0A8J8XP37, A6KMX6
      Related
      ENSRNOP00000022598.5, ENSRNOT00000022598.8
      Conserved Domains (1) summary
      pfam03253
      Location:56 → 340
      UT; Urea transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      73840568..73883925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772170.3 → XP_008770392.1  urea transporter 1 isoform X3

      See identical proteins and their annotated locations for XP_008770392.1

      UniProtKB/Swiss-Prot
      E9PSP0, P70633, P97689
      UniProtKB/TrEMBL
      A0A8J8XP37, A6KMX6
      Related
      ENSRNOP00000088113.1, ENSRNOT00000114974.2
      Conserved Domains (1) summary
      pfam03253
      Location:56 → 340
      UT; Urea transporter

    2. XM_008772169.4 → XP_008770391.1  urea transporter 1 isoform X2

      UniProtKB/Swiss-Prot
      E9PSP0, P70633, P97689
      UniProtKB/TrEMBL
      H9KVF0, M0R8C6
      Related
      ENSRNOP00000065722.2, ENSRNOT00000074572.5
      Conserved Domains (1) summary
      pfam03253
      Location:75 → 358
      UT; Urea transporter

    3. XM_039097052.1 → XP_038952980.1  urea transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      E9PSP0, P70633, P97689
      UniProtKB/TrEMBL
      A0A8I5ZWN6
      Conserved Domains (1) summary
      pfam03253
      Location:110 → 394
      UT; Urea transporter

    4. XM_008772168.3 → XP_008770390.1  urea transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      E9PSP0, P70633, P97689
      UniProtKB/TrEMBL
      A0A8I5ZWN6
      Related
      ENSRNOP00000083480.1, ENSRNOT00000109500.2
      Conserved Domains (1) summary
      pfam03253
      Location:110 → 394
      UT; Urea transporter

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138834.1: Suppressed sequence

      Description
      NM_138834.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97689.2 GenPept UniProtKB/Swiss-Prot:P97689

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