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    Mtrf1 mitochondrial translation release factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtrf1provided by RGD
    Official Full Name
    mitochondrial translation release factor 1provided by RGD
    Primary source
    RGD:1584329
    See related
    EnsemblRapid:ENSRNOG00000047106 AllianceGenome:RGD:1584329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable translation release factor activity, codon specific. Predicted to be involved in mitochondrial translational termination. Predicted to be active in mitochondrion. Orthologous to human MTRF1 (mitochondrial translation release factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 126.5), Heart (RPKM 113.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtrf1 in Genome Data Viewer
    Location:
    15q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61185958..61213783)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54776885..54804699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61662000..61689867)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene glutamate-ammonia ligase, pseudogene 1 Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene U2 spliceosomal RNA Neighboring gene kelch repeat and BTB domain containing 7 Neighboring gene ribosomal protein S24, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation release factor activity, codon specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide chain release factor 1, mitochondrial
    Names
    mitochondrial translational release factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399523.1 → NP_001386452.1  peptide chain release factor 1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTZ0, A6HTZ1, M0RDC8
      Conserved Domains (1) summary
      cl40670
      Location:80 → 436
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      61185958..61213783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252368.5 → XP_006252430.1  peptide chain release factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006252430.1

      UniProtKB/TrEMBL
      A6HTZ0, A6HTZ1, M0RDC8
      Conserved Domains (1) summary
      cl40670
      Location:80 → 436
      PCRF; PCRF domain

    2. XM_006252367.5 → XP_006252429.1  peptide chain release factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006252429.1

      UniProtKB/TrEMBL
      A6HTZ0, A6HTZ1, M0RDC8
      Conserved Domains (1) summary
      cl40670
      Location:80 → 436
      PCRF; PCRF domain

    3. XM_063274643.1 → XP_063130713.1  peptide chain release factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q661, A6HTZ1
      Related
      ENSRNOP00000067626.2, ENSRNOT00000072969.5

    4. XM_063274644.1 → XP_063130714.1  peptide chain release factor 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6HTZ1
      Related
      ENSRNOP00000076141.3, ENSRNOT00000093163.3

    5. XM_039094051.2 → XP_038949979.1  peptide chain release factor 1, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl40670
      Location:1 → 226
      PCRF; PCRF domain

    6. XM_039094050.2 → XP_038949978.1  peptide chain release factor 1, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl40670
      Location:1 → 226
      PCRF; PCRF domain

    7. XM_008770927.4 → XP_008769149.1  peptide chain release factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008769149.1

      UniProtKB/TrEMBL
      A6HTZ0, A6HTZ1, M0RDC8
      Conserved Domains (1) summary
      cl40670
      Location:80 → 436
      PCRF; PCRF domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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