Sorbs2 sorbin and SH3 domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sorbs2provided by RGD
Official Full Name: sorbin and SH3 domain containing 2provided by RGD
Primary source: RGD:620061
See related: EnsemblRapid:ENSRNOG00000013391 AllianceGenome:RGD:620061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Argbp2
Summary: Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in cell growth involved in cardiac muscle cell development. Located in dendrite and neuronal cell body. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 391.2), Heart (RPKM 367.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (53167795..53481300, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (46435220..46748743, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (49626205..49820223, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that nArgBP2 functions to regulate spine morphogenesis and subsequent spine-synapse formation at glutamatergic synapses.
Title: nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology.
Data suggest that SORBS2 is up-regulated in podocytes of glomeruli and may be associated with development and progression of diabetic nephropathy in a model of type 2 diabetes, possibly through reorganization of actin filaments.
Title: Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.
ArgBP2 is a scaffold protein that control the balance between adhesion and motility by coordinating the function of multiple signaling pathways converging on the actin cytoskeleton.
Title: The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW532810 (e-PCR)
- UniSTS:245593

BE114613 (e-PCR)
- UniSTS:261522

D8Mit297 (e-PCR), detects polymorphism
- UniSTS:131509

AW434052 (e-PCR)
- UniSTS:248769

BE109620 (e-PCR)
- UniSTS:248308

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorbin and SH3 domain-containing protein 2

Names: Arg/Abl-interacting protein ArgBP2; arg-binding protein 2; arg/Abl-interacting protein 2; nArgBP2; neural ArgBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053770.3 → NP_446222.3 sorbin and SH3 domain-containing protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

O35413, Q923T8

Related

ENSRNOP00000098300.2, ENSRNOT00000120667.2

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1136 → 1196

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:962 → 1016

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1037 → 1093

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

53167795..53481300 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094137.2 → XP_038950065.1 sorbin and SH3 domain-containing protein 2 isoform X15

UniProtKB/Swiss-Prot

O35413, Q923T8

UniProtKB/TrEMBL

A6JPR1

Related

ENSRNOP00000094779.3, ENSRNOT00000111730.3

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1135 → 1195

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:961 → 1015

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1036 → 1092

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_063275002.1 → XP_063131072.1 sorbin and SH3 domain-containing protein 2 isoform X12

UniProtKB/Swiss-Prot

O35413, Q923T8

Related

ENSRNOP00000089017.2, ENSRNOT00000115009.2
XM_063275036.1 → XP_063131106.1 sorbin and SH3 domain-containing protein 2 isoform X46

UniProtKB/TrEMBL

A0A8I5ZQ23

Related

ENSRNOP00000098297.2, ENSRNOT00000120664.2
XM_063275034.1 → XP_063131104.1 sorbin and SH3 domain-containing protein 2 isoform X44

UniProtKB/TrEMBL

A0A8I5ZV05
XM_063275031.1 → XP_063131101.1 sorbin and SH3 domain-containing protein 2 isoform X41

UniProtKB/TrEMBL

A6JPQ9
XM_063275032.1 → XP_063131102.1 sorbin and SH3 domain-containing protein 2 isoform X42

UniProtKB/TrEMBL

A6JPR0
XM_063275029.1 → XP_063131099.1 sorbin and SH3 domain-containing protein 2 isoform X40

UniProtKB/TrEMBL

A6JPR0
XM_063275028.1 → XP_063131098.1 sorbin and SH3 domain-containing protein 2 isoform X39

UniProtKB/TrEMBL

A6JPR0
XM_063275019.1 → XP_063131089.1 sorbin and SH3 domain-containing protein 2 isoform X31

UniProtKB/TrEMBL

A0A8I5ZQ23
XM_063275027.1 → XP_063131097.1 sorbin and SH3 domain-containing protein 2 isoform X38

UniProtKB/TrEMBL

A6JPR0
XM_063275025.1 → XP_063131095.1 sorbin and SH3 domain-containing protein 2 isoform X37

UniProtKB/TrEMBL

A6JPR0
XM_063275024.1 → XP_063131094.1 sorbin and SH3 domain-containing protein 2 isoform X36

UniProtKB/TrEMBL

A6JPR0
XM_063275005.1 → XP_063131075.1 sorbin and SH3 domain-containing protein 2 isoform X17

UniProtKB/Swiss-Prot

O35413, Q923T8
XM_063275018.1 → XP_063131088.1 sorbin and SH3 domain-containing protein 2 isoform X30

UniProtKB/TrEMBL

A6JPR0
XM_063275017.1 → XP_063131087.1 sorbin and SH3 domain-containing protein 2 isoform X29

UniProtKB/TrEMBL

A6JPR0
XM_063275010.1 → XP_063131080.1 sorbin and SH3 domain-containing protein 2 isoform X22

UniProtKB/TrEMBL

A0A8I6AA99

Related

ENSRNOP00000091476.2, ENSRNOT00000113085.2
XM_063275009.1 → XP_063131079.1 sorbin and SH3 domain-containing protein 2 isoform X21

UniProtKB/TrEMBL

A0A8I6AA99
XM_063275023.1 → XP_063131093.1 sorbin and SH3 domain-containing protein 2 isoform X35

UniProtKB/TrEMBL

A6JPR0
XM_063275022.1 → XP_063131092.1 sorbin and SH3 domain-containing protein 2 isoform X34

UniProtKB/TrEMBL

A6JPR0
XM_063275004.1 → XP_063131074.1 sorbin and SH3 domain-containing protein 2 isoform X14

UniProtKB/Swiss-Prot

O35413, Q923T8
XM_063275016.1 → XP_063131086.1 sorbin and SH3 domain-containing protein 2 isoform X28

UniProtKB/TrEMBL

A0A8I5ZQ23
XM_063275021.1 → XP_063131091.1 sorbin and SH3 domain-containing protein 2 isoform X33

UniProtKB/TrEMBL

A6JPR0
XM_063275003.1 → XP_063131073.1 sorbin and SH3 domain-containing protein 2 isoform X13

UniProtKB/Swiss-Prot

O35413, Q923T8

UniProtKB/TrEMBL

F1LPM3

Related

ENSRNOP00000029182.5, ENSRNOT00000029628.8
XM_063275000.1 → XP_063131070.1 sorbin and SH3 domain-containing protein 2 isoform X11

UniProtKB/Swiss-Prot

O35413, Q923T8
XM_063275015.1 → XP_063131085.1 sorbin and SH3 domain-containing protein 2 isoform X27

UniProtKB/TrEMBL

A6JPR0
XM_063275014.1 → XP_063131084.1 sorbin and SH3 domain-containing protein 2 isoform X26

UniProtKB/TrEMBL

A6JPR0
XM_063274998.1 → XP_063131068.1 sorbin and SH3 domain-containing protein 2 isoform X9

UniProtKB/Swiss-Prot

O35413, Q923T8

Related

ENSRNOP00000098299.1, ENSRNOT00000120666.2
XM_063274997.1 → XP_063131067.1 sorbin and SH3 domain-containing protein 2 isoform X8

UniProtKB/Swiss-Prot

O35413, Q923T8
XM_063275013.1 → XP_063131083.1 sorbin and SH3 domain-containing protein 2 isoform X25

UniProtKB/TrEMBL

A0A8I6AFA3
XM_063275012.1 → XP_063131082.1 sorbin and SH3 domain-containing protein 2 isoform X24

UniProtKB/TrEMBL

A0A8I6AFA3
XM_063274996.1 → XP_063131066.1 sorbin and SH3 domain-containing protein 2 isoform X7

UniProtKB/Swiss-Prot

O35413, Q923T8
XM_063275011.1 → XP_063131081.1 sorbin and SH3 domain-containing protein 2 isoform X23

UniProtKB/TrEMBL

A0A8I6AA99
XM_063275008.1 → XP_063131078.1 sorbin and SH3 domain-containing protein 2 isoform X20

UniProtKB/TrEMBL

A0A8I6AA99
XM_063275007.1 → XP_063131077.1 sorbin and SH3 domain-containing protein 2 isoform X19

UniProtKB/TrEMBL

A0A8I6AA99

Related

ENSRNOP00000090759.2, ENSRNOT00000096919.2
XM_063275006.1 → XP_063131076.1 sorbin and SH3 domain-containing protein 2 isoform X18

UniProtKB/TrEMBL

A0A8I6AA99
XM_063274994.1 → XP_063131064.1 sorbin and SH3 domain-containing protein 2 isoform X5
XM_063274991.1 → XP_063131061.1 sorbin and SH3 domain-containing protein 2 isoform X2
XM_063274995.1 → XP_063131065.1 sorbin and SH3 domain-containing protein 2 isoform X6
XM_063274993.1 → XP_063131063.1 sorbin and SH3 domain-containing protein 2 isoform X4
XM_063274992.1 → XP_063131062.1 sorbin and SH3 domain-containing protein 2 isoform X3
XM_063274989.1 → XP_063131059.1 sorbin and SH3 domain-containing protein 2 isoform X1
XM_063275037.1 → XP_063131107.1 sorbin and SH3 domain-containing protein 2 isoform X46

UniProtKB/TrEMBL

A0A8I5ZQ23
XM_063275035.1 → XP_063131105.1 sorbin and SH3 domain-containing protein 2 isoform X45

UniProtKB/TrEMBL

A0A8I5ZQ23
XM_063275033.1 → XP_063131103.1 sorbin and SH3 domain-containing protein 2 isoform X43

UniProtKB/TrEMBL

A0A8I5ZV05

Related

ENSRNOP00000077815.1, ENSRNOT00000118135.3
XM_063275020.1 → XP_063131090.1 sorbin and SH3 domain-containing protein 2 isoform X32

UniProtKB/TrEMBL

A0A8I5ZQ23, A0A8I6ABV1
XM_063275030.1 → XP_063131100.1 sorbin and SH3 domain-containing protein 2 isoform X40

UniProtKB/TrEMBL

A6JPR0
XM_063275026.1 → XP_063131096.1 sorbin and SH3 domain-containing protein 2 isoform X37

UniProtKB/TrEMBL

A6JPR0
XM_039094138.2 → XP_038950066.1 sorbin and SH3 domain-containing protein 2 isoform X16

UniProtKB/Swiss-Prot

O35413, Q923T8

Conserved Domains (4) summary

cd11917
Location:1120 → 1180

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:946 → 1000

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1021 → 1077

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

pfam02208
Location:170 → 211

Sorb; Sorbin homologous domain
XM_063274999.1 → XP_063131069.1 sorbin and SH3 domain-containing protein 2 isoform X10

UniProtKB/Swiss-Prot

O35413, Q923T8