Il3ra interleukin 3 receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il3raprovided by RGD
Official Full Name: interleukin 3 receptor subunit alphaprovided by RGD
Primary source: RGD:628728
See related: EnsemblRapid:ENSRNOG00000001325 AllianceGenome:RGD:628728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyrl
Summary: Predicted to enable cytokine binding activity and interleukin-3 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within interleukin-3-mediated signaling pathway. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 66.9), Lung (RPKM 32.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21431848..21437336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16318081..16323781, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (18534762..18542508, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-3 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-3	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-3 receptor subunit alpha

Names: cytokine receptor-like protein CYRL; interleukin 3 receptor, alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139260.3 → NP_640353.2 interleukin-3 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_640353.2

Status: VALIDATED

Source sequence(s)

BP475867, FM042837, FM046911, JAXUCZ010000012

UniProtKB/TrEMBL

E9PSX4

Related

ENSRNOP00000001792.4, ENSRNOT00000001792.6

Conserved Domains (1) summary

cl21522
Location:124 → 218

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

21431848..21437336 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248989.5 → XP_006249051.1 interleukin-3 receptor subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006249051.1

UniProtKB/TrEMBL

E9PSX4

Conserved Domains (1) summary

cl21522
Location:124 → 218

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...