Rcan1 regulator of calcineurin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rcan1provided by RGD
Official Full Name: regulator of calcineurin 1provided by RGD
Primary source: RGD:631338
See related: EnsemblRapid:ENSRNOG00000001979 AllianceGenome:RGD:631338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dscr1; Mcip1
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and identical protein binding activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; response to estrogen; and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 639.6), Liver (RPKM 480.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (45108123..45188065, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (31622208..31702150, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (32539689..32620274, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of cardiomyocytes of sepsis rats.
Title: MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of cardiomyocytes of sepsis rats.
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs.
Title: The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs.
Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
RCAN1 plays a critical role in spinal cord injury.
Title: Critical role of regulator of calcineurin 1 in spinal cord injury.
We propose that increased RCAN1-4 expression and the signal transduction pathways it regulates represent important components of the physiological adaptation to exercise-induced oxidative stress.
Title: The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle.
Rcan1 downregulation impaired neural progenitor proliferation and led to defects in radial migration and periventricular heterotopia.
Title: Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia.
calcineurin/NFAT pathway mediates the upregulation of PAI-1 by NGF
Title: NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.
RCAN1 induced the expression of the CREB target gene, Bcl-2.
Title: CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death.
RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells
Title: Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.
RCAN1 acts as an important regulatory component in the control of CREB signaling.
Title: The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

RH130538 (e-PCR)
- UniSTS:213822

RH130128 (e-PCR)
- UniSTS:213416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2B binding	TAS Traceable Author Statement more info	PubMed
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
involved_in short-term memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within short-term memory	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcipressin-1

Names: Down syndrome critical region gene 1; Down syndrome critical region homolog 1; down syndrome critical region protein 1 homolog; myocyte-enriched calcineurin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.