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    Aip aryl-hydrocarbon receptor-interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aipprovided by RGD
    Official Full Name
    aryl-hydrocarbon receptor-interacting proteinprovided by RGD
    Primary source
    RGD:628619
    See related
    EnsemblRapid:ENSRNOG00000022289 AllianceGenome:RGD:628619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    XAP2
    Summary
    Enables enzyme binding activity. Involved in protein kinase A signaling. Predicted to be located in cytosol and plasma membrane. Predicted to be part of aryl hydrocarbon receptor complex. Human ortholog(s) of this gene implicated in pituitary adenoma 1. Orthologous to human AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 116.4), Lung (RPKM 106.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aip in Genome Data Viewer
    Location:
    1q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210837473..210848691, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201408002..201419220, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219361859..219373924, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 2 associated protein 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene transmembrane protein 134 Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aip regulates cAMP signalling and GH secretion in GH3 cells. Formosa R, et al. Endocr Relat Cancer, 2013 Aug. PMID 23702468
    2. Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line. Fukuda T, et al. PLoS One, 2016. PMID 27706259, Free PMC Article
    3. Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines. Pollenz RS, et al. J Biol Chem, 2005 Sep 30. PMID 16085934
    4. RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. Garcia-Rendueles AR, et al. Oncogene, 2021 Nov. PMID 34588620, Free PMC Article
    5. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. Vargiolu M, et al. J Clin Endocrinol Metab, 2009 Jul. PMID 19366855

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
      Title: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
    2. Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation.
      Title: Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
    3. Aip regulates cAMP signalling and growth hormone secretion in GH3 cells.
      Title: Aip regulates cAMP signalling and GH secretion in GH3 cells.
    4. results suggest that XAP2 functionally interacts with PDE4A5 in cells
      Title: Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
    5. The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in rat cell lines was determined.
      Title: Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GAF domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein maturation by protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aryl hydrocarbon receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AH receptor-interacting protein
    Names
    HBV-X associated protein
    immunophilin XAP2
    NP_758830.2
    XP_006230762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172327.3 → NP_758830.2  AH receptor-interacting protein

      See identical proteins and their annotated locations for NP_758830.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5FWY5, Q8CGW7
      UniProtKB/TrEMBL
      A0A8L2PZ29, A6HYT6
      Related
      ENSRNOP00000075162.1, ENSRNOT00000091542.3
      Conserved Domains (2) summary
      sd00006
      Location:183 → 225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:29 → 90
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210837473..210848691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230700.5 → XP_006230762.1  AH receptor-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006230762.1

      UniProtKB/Swiss-Prot
      Q5FWY5, Q8CGW7
      UniProtKB/TrEMBL
      A0A8L2PZ29, A6HYT6
      Conserved Domains (2) summary
      sd00006
      Location:183 → 225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:29 → 90
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWY5.1 GenPept UniProtKB/Swiss-Prot:Q5FWY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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