Mars1 methionyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mars1provided by RGD
Official Full Name: methionyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1305321
See related: EnsemblRapid:ENSRNOG00000025459 AllianceGenome:RGD:1305321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mars
Summary: Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to epidermal growth factor stimulus; and cellular response to platelet-derived growth factor stimulus. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 330.6), Adrenal (RPKM 302.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65006456..65023880, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63121142..63138550, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70585011..70602425, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141558 (e-PCR)
- UniSTS:223552

RH128750 (e-PCR)
- UniSTS:212058

PMC150726P4 (e-PCR)
- UniSTS:271076

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables methionine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in methionyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methionine--tRNA ligase, cytoplasmic

Names: methionine-tRNA synthetase

NP_001121131.1

EC 6.1.1.10

XP_006241513.1

EC 6.1.1.10

XP_038934683.1

EC 6.1.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127659.1 → NP_001121131.1 methionine--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A8E9, D3Z941

Related

ENSRNOP00000089312.1, ENSRNOT00000107571.2

Conserved Domains (3) summary

cd10307
Location:77 → 179

GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes

PLN02610
Location:258 → 878

PLN02610; probable methionyl-tRNA synthetase

pfam18485
Location:1 → 74

GST_N_5; Glutathione S-transferase, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

65006456..65023880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241451.5 → XP_006241513.1 methionine--tRNA ligase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_006241513.1

UniProtKB/TrEMBL

A0A8I5ZKR4, A0A8I6A8E9, A6HQU9

Related

ENSRNOP00000078365.1, ENSRNOT00000106342.2

Conserved Domains (7) summary

cd07957
Location:644 → 773

Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases

cd00814
Location:267 → 635

MetRS_core; catalytic core domain of methioninyl-tRNA synthetases

cd10307
Location:77 → 179

GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes

COG0625
Location:47 → 189

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

PRK12268
Location:266 → 821

PRK12268; methionyl-tRNA synthetase; Reviewed

cd00939
Location:855 → 899

MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...

cl00388
Location:1 → 68

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
XM_039078755.2 → XP_038934683.1 methionine--tRNA ligase, cytoplasmic isoform X2

Conserved Domains (2) summary

PLN02610
Location:1 → 515

PLN02610; probable methionyl-tRNA synthetase

cd00939
Location:531 → 575

MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...