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    Nrip2 nuclear receptor interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689619, updated on 9-Dec-2024

    Summary

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    Symbol
    Nrip2provided by RGD
    Full Name
    nuclear receptor interacting protein 2provided by RGD
    Primary source
    RGD:1589959
    See related
    EnsemblRapid:ENSRNOG00000063347 AllianceGenome:RGD:1589959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human NRIP2 (nuclear receptor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 34.8), Lung (RPKM 25.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrip2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163359592..163370144)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161673964..161684055)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161719434..161729673)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene uncharacterized LOC120102402 Neighboring gene FKBP prolyl isomerase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Greiner EF, et al. Proc Natl Acad Sci U S A, 2000 Jun 20. PMID 10860982, Free PMC Article
    2. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor interacting protein 2; nuclear receptor-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431912.1 → NP_001418841.1  nuclear receptor interacting protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6APM8

    2. NM_001431913.1 → NP_001418842.1  nuclear receptor interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    3. NM_001431914.1 → NP_001418843.1  nuclear receptor interacting protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IM10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163359592..163370144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593047.3 → XP_017448536.1  nuclear receptor-interacting protein 2 isoform X3

    2. XM_006237431.5 → XP_006237493.1  nuclear receptor-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237493.1

      Conserved Domains (1) summary
      cl11403
      Location:110 → 199
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    3. XM_063286865.1 → XP_063142935.1  nuclear receptor-interacting protein 2 isoform X4

    4. XM_001071392.8 → XP_001071392.2  nuclear receptor-interacting protein 2 isoform X2

      Related
      ENSRNOP00000094217.1, ENSRNOT00000105666.2
      Conserved Domains (1) summary
      cl11403
      Location:110 → 206
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein Strain
    Heading Accession and Version

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