Creb3l3 cAMP responsive element binding protein 3-like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Creb3l3provided by RGD
Official Full Name: cAMP responsive element binding protein 3-like 3provided by RGD
Primary source: RGD:1308152
See related: EnsemblRapid:ENSRNOG00000032202 AllianceGenome:RGD:1308152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in nucleus. Orthologous to human CREB3L3 (cAMP responsive element binding protein 3 like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 989.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9273320..9281755)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8622614..8631053)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11490852..11499287)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of hepatocyte Crebh and Insig1/Insig2a (insulin induced gene products 1/2) can be up-regulated by dietary factors (here, dietary supplementation with R-alpha-lipoic acid, an anti-hypertriglyceridemic agent).
Title: Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH
Title: Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 3-like protein 3

Names: cAMP-responsive element-binding protein 3-like protein 3; transcription factor CREB-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012115.1 → NP_001012115.1 cyclic AMP-responsive element-binding protein 3-like protein 3

See identical proteins and their annotated locations for NP_001012115.1

Status: PROVISIONAL

Source sequence(s)

BC089877

UniProtKB/Swiss-Prot

Q5FVM5

UniProtKB/TrEMBL

A6K8C7

Related

ENSRNOP00000044840.3, ENSRNOT00000044484.5

Conserved Domains (2) summary

PHA03185
Location:40 → 139

PHA03185; UL14 tegument protein; Provisional

cd14689
Location:240 → 300

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain