L3hypdh trans-L-3-hydroxyproline dehydratase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: L3hypdhprovided by RGD
Official Full Name: trans-L-3-hydroxyproline dehydrataseprovided by RGD
Primary source: RGD:1305721
See related: AllianceGenome:RGD:1305721
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305721
Summary: Predicted to enable hydro-lyase activity. Orthologous to human L3HYPDH (trans-L-3-hydroxyproline dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 286.6), Liver (RPKM 65.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (96372243..96383039, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (90636310..90647106, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (94824112..94834908, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydro-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydro-lyase activity	ISO Inferred from Sequence Orthology more info
NOT enables proline racemase activity	ISO Inferred from Sequence Orthology more info
enables trans-L-3-hydroxyproline dehydratase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trans-3-hydroxy-L-proline dehydratase

Names: L-3-hydroxyproline dehydratase (trans-)

NP_001101501.1

EC 4.2.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108031.1 → NP_001101501.1 trans-3-hydroxy-L-proline dehydratase

See identical proteins and their annotated locations for NP_001101501.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HC29, D3ZV91

Conserved Domains (2) summary

PRK13970
Location:20 → 347

PRK13970; hydroxyproline-2-epimerase; Provisional

pfam05544
Location:22 → 352

Pro_racemase; Proline racemase