Mier3 MIER family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mier3provided by RGD
Official Full Name: MIER family member 3provided by RGD
Primary source: RGD:1311241
See related: EnsemblRapid:ENSRNOG00000013121 AllianceGenome:RGD:1311241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311241
Summary: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 158.8), Spleen (RPKM 114.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (45021167..45049745)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (43287546..43316422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (43266301..43295175)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MIER3 (e-PCR)
- UniSTS:505754

stSG625181 (e-PCR)
- UniSTS:456371

stSG625182 (e-PCR)
- UniSTS:456372

stSG625183 (e-PCR)
- UniSTS:456373

ECD09476 (e-PCR)
- UniSTS:290519

REN28465 (e-PCR)
- UniSTS:353265

REN28471 (e-PCR)
- UniSTS:353271

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT contributes_to histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mesoderm induction early response protein 3

Names: mesoderm induction early response 1, family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168000.2 → NP_001161472.1 mesoderm induction early response protein 3

See identical proteins and their annotated locations for NP_001161472.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I5N1, D3ZE77

Conserved Domains (2) summary

cd11661
Location:255 → 299

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:149 → 197

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

45021167..45049745

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231925.4 → XP_006231987.3 mesoderm induction early response protein 3 isoform X2

UniProtKB/TrEMBL

A6I5N1, D3ZE77
XM_006231924.5 → XP_006231986.1 mesoderm induction early response protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JUL8, D3ZE77

Related

ENSRNOP00000069147.1, ENSRNOT00000087031.3

Conserved Domains (3) summary

smart00717
Location:280 → 327

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:282 → 326

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:176 → 224

ELM2; ELM2 domain
XM_039102181.2 → XP_038958109.1 mesoderm induction early response protein 3 isoform X2

UniProtKB/TrEMBL

A6I5N1, D3ZE77

Conserved Domains (2) summary

cd11661
Location:255 → 299

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:149 → 197

ELM2; ELM2 domain
XM_063281723.1 → XP_063137793.1 mesoderm induction early response protein 3 isoform X2

UniProtKB/TrEMBL

A6I5N1, D3ZE77