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    Faxdc2 fatty acid hydroxylase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faxdc2provided by RGD
    Official Full Name
    fatty acid hydroxylase domain containing 2provided by RGD
    Primary source
    RGD:1586284
    See related
    EnsemblRapid:ENSRNOG00000027259 AllianceGenome:RGD:1586284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable iron ion binding activity and oxidoreductase activity. Predicted to be involved in positive regulation of megakaryocyte differentiation and positive regulation of protein phosphorylation. Predicted to be located in cytoplasm. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 241.5), Lung (RPKM 198.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Faxdc2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42747323..42772156, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42245808..42271679, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43500825..43526376, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480691 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene ATP synthase membrane subunit K like 1 Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene CCR4-NOT transcription complex, subunit 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel function of FAXDC2 in megakaryopoiesis. Jin Q, et al. Blood Cancer J, 2016 Sep 30. PMID 27689744, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid hydroxylase domain containing 2; fatty acid hydroxylase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430287.1 → NP_001417216.1  fatty acid hydroxylase domain containing 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HEQ4

    2. NM_001430288.1 → NP_001417217.1  fatty acid hydroxylase domain containing 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HEQ4

    3. NM_001430289.1 → NP_001417218.1  fatty acid hydroxylase domain containing 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HEQ4

    4. NM_001430290.1 → NP_001417219.1  fatty acid hydroxylase domain containing 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZS99

    5. NM_001430291.1 → NP_001417220.1  fatty acid hydroxylase domain containing 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZS99

    6. NM_001430292.1 → NP_001417221.1  fatty acid hydroxylase domain containing 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    7. NM_001430293.1 → NP_001417222.1  fatty acid hydroxylase domain containing 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    8. NM_001430294.1 → NP_001417223.1  fatty acid hydroxylase domain containing 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42747323..42772156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087211.2 → XP_038943139.1  fatty acid hydroxylase domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      pfam04116
      Location:192 → 266
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    2. XM_017597634.3 → XP_017453123.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F1M8Z0
      Related
      ENSRNOP00000101741.1, ENSRNOT00000161793.1

    3. XM_039087209.2 → XP_038943137.1  fatty acid hydroxylase domain-containing protein 2 isoform X3

      Related
      ENSRNOP00000033145.7, ENSRNOT00000036481.7
      Conserved Domains (1) summary
      pfam04116
      Location:152 → 276
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    4. XM_039087212.2 → XP_038943140.1  fatty acid hydroxylase domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      pfam04116
      Location:135 → 259
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    5. XM_063270030.1 → XP_063126100.1  fatty acid hydroxylase domain-containing protein 2 isoform X3

    6. XM_039087213.2 → XP_038943141.1  fatty acid hydroxylase domain-containing protein 2 isoform X6

      Conserved Domains (1) summary
      pfam04116
      Location:76 → 200
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    7. XM_039087208.2 → XP_038943136.1  fatty acid hydroxylase domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      pfam04116
      Location:246 → 354
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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