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    Anks1b ankyrin repeat and sterile alpha motif domain containing 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anks1bprovided by RGD
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 1Bprovided by RGD
    Primary source
    RGD:1565556
    See related
    EnsemblRapid:ENSRNOG00000024870 AllianceGenome:RGD:1565556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EB-1; AIDA-1; RGD1565556
    Summary
    Predicted to enable ephrin receptor binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within receptor localization to synapse. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic density, intracellular component; and presynaptic cytosol. Orthologous to human ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 313.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anks1b in Genome Data Viewer
    Location:
    7q13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (26200649..27366552)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (24313339..25479307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (30507135..31684604)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene actin related protein 6 Neighboring gene bridge-like lipid transfer protein family member 3B Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134479858 Neighboring gene uncharacterized LOC120093796 Neighboring gene uncharacterized LOC108351597 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120093797 Neighboring gene uncharacterized LOC134479657 Neighboring gene uncharacterized LOC120093795 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 4 Neighboring gene uncharacterized LOC134479857 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions. Dosemeci A, et al. PLoS One, 2015. PMID 26356309, Free PMC Article
    2. Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain. Jacob AL, et al. J Comp Neurol, 2010 Aug 15. PMID 20575057, Free PMC Article
    3. Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Jordan BA, et al. Nat Neurosci, 2007 Apr. PMID 17334360
    4. CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core. Dosemeci A, et al. FEBS Lett, 2016 Sep. PMID 27477489, Free PMC Article
    5. PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition. Kroker KS, et al. Neurobiol Aging, 2014 Sep. PMID 24746365

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaMKII-mediated redistribution of AIDA-1 is similar to that observed for SynGAP. CaMKII-mediated removal of two abundant PSD-95-binding proteins from the PSD core during activity is expected to initiate a molecular reorganization at the PSD.
      Title: CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core.
    2. localization as well as the activity-induced redistribution of AIDA-1 at the postsynaptic density, was examined.
      Title: AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions.
    3. It impairs hippocampallong-term potentiation.
      Title: PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.
    4. data suggest that AIDA-1 serves as a direct signaling link between synapses and the nucleus in adult rat brain.
      Title: Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission, postsynaptic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynapse to nucleus signaling pathway EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity by receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Names
    E2A-PBX1-associated protein
    amyloid-beta protein intracellular domain-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271371.3 → NP_001258300.2  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1042 → 1191
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001414940.1 → NP_001401869.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P0C6S7
      UniProtKB/TrEMBL
      A0A8I6GAL6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      26200649..27366552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079051.2 → XP_038934979.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X13

      Conserved Domains (4) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)
      cl15755
      Location:807 → 840
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_063263442.1 → XP_063119512.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X11

      UniProtKB/Swiss-Prot
      P0C6S7

    3. XM_039079050.2 → XP_038934978.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X12

      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (5) summary
      cd09499
      Location:759 → 825
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:830 → 894
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:934 → 1083
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_017594833.3 → XP_017450322.2  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X7

      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1067 → 1216
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_008765241.4 → XP_008763463.3  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X10

      UniProtKB/Swiss-Prot
      P0C6S7
      Related
      ENSRNOP00000056036.6, ENSRNOT00000059269.7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:982 → 1131
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_017594832.3 → XP_017450321.2  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X5

      UniProtKB/Swiss-Prot
      P0C6S7
      Related
      ENSRNOP00000078170.2, ENSRNOT00000114777.2
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1067 → 1216
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_017594830.3 → XP_017450319.2  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X2

      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1067 → 1216
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_063263441.1 → XP_063119511.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X8

      UniProtKB/Swiss-Prot
      P0C6S7

    9. XM_039079046.2 → XP_038934974.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X3

      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1066 → 1215
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_039079047.2 → XP_038934975.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X6

      UniProtKB/Swiss-Prot
      P0C6S7
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1042 → 1191
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_039079048.2 → XP_038934976.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X9

      UniProtKB/Swiss-Prot
      P0C6S7
      Related
      ENSRNOP00000108068.1, ENSRNOT00000150575.1
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:982 → 1131
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_017594828.3 → XP_017450317.2  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X1

      UniProtKB/Swiss-Prot
      P0C6S7
      Related
      ENSRNOP00000084534.2, ENSRNOT00000102313.2
      Conserved Domains (6) summary
      PHA02874
      Location:7 → 386
      PHA02874; ankyrin repeat protein; Provisional
      cd09499
      Location:807 → 873
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:878 → 942
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:1067 → 1216
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:58 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:63 → 158
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_063263440.1 → XP_063119510.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X4

      UniProtKB/Swiss-Prot
      P0C6S7

    14. XM_063263443.1 → XP_063119513.1  ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X14

      UniProtKB/TrEMBL
      A0A8I5Y9Y6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6S7.1 GenPept UniProtKB/Swiss-Prot:P0C6S7

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