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    Zfp668 zinc finger protein 668 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp668provided by RGD
    Official Full Name
    zinc finger protein 668provided by RGD
    Primary source
    RGD:1308623
    See related
    EnsemblRapid:ENSRNOG00000016683 AllianceGenome:RGD:1308623
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf668; RGD1308623
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in DNA repair and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF668 (zinc finger protein 668). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 33.8), Brain (RPKM 25.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp668 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191905112..191915436, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182474633..182484957, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199310935..199321231, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC134483916 Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 646 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Kim S, et al. Immunity, 2004 Nov. PMID 15539151
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 668

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107553.1 → NP_001101023.1  zinc finger protein 668

      See identical proteins and their annotated locations for NP_001101023.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I9V8
      Related
      ENSRNOP00000022452.5, ENSRNOT00000022452.9
      Conserved Domains (4) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:544 → 566
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210 → 235
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191905112..191915436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589218.2 → XP_017444707.1  zinc finger protein 668 isoform X3

      UniProtKB/TrEMBL
      D3ZPP0

    2. XM_039078439.2 → XP_038934367.1  zinc finger protein 668 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A933
      Conserved Domains (2) summary
      COG5048
      Location:76 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_017589216.3 → XP_017444705.1  zinc finger protein 668 isoform X3

      UniProtKB/TrEMBL
      D3ZPP0

    4. XM_017589214.3 → XP_017444703.1  zinc finger protein 668 isoform X1

      Related
      ENSRNOP00000108674.1, ENSRNOT00000168166.1

    5. XM_039078442.2 → XP_038934370.1  zinc finger protein 668 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A933
      Related
      ENSRNOP00000089577.1, ENSRNOT00000097525.2
      Conserved Domains (2) summary
      COG5048
      Location:76 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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