Tmem35a transmembrane protein 35A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem35aprovided by RGD
Official Full Name: transmembrane protein 35Aprovided by RGD
Primary source: RGD:1303093
See related: EnsemblRapid:ENSRNOG00000001506 AllianceGenome:RGD:1303093
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RSEP4; Tmem35
Summary: Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM35A (transmembrane protein 35A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 230.3), Uterus (RPKM 30.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (101796623..101807471)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97503350..97514198)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (105134498..105145346)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM35/TUF1 is a candidate for modulating neurite outgrowth in the ZG after sodium depletion.
Title: Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine receptor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylcholine receptor regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: novel acetylcholine receptor chaperone

Names: TMEM35 gene-derived unknown factor 1; spinal cord expression protein 4; transmembrane protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.