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    Stambpl1 STAM binding protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stambpl1provided by RGD
    Official Full Name
    STAM binding protein-like 1provided by RGD
    Primary source
    RGD:1583011
    See related
    EnsemblRapid:ENSRNOG00000050224 AllianceGenome:RGD:1583011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable K63-linked deubiquitinase activity. Predicted to be involved in cellular response to L-leucine and positive regulation of TORC1 signaling. Predicted to be active in endosome and membrane. Orthologous to human STAMBPL1 (STAM binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 108.4), Spleen (RPKM 41.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stambpl1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241095695..241158225)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (231699620..231745034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252490125..252536113)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lipase, family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene actin alpha 2, smooth muscle Neighboring gene death effector domain-containing, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMSH-like protease
    NP_001108520.1
    XP_006231358.1
    XP_006231359.1
    XP_006231361.1
    XP_008758568.1
    XP_008758571.1
    XP_038946982.1
    XP_038946993.1
    XP_038947011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115048.2 → NP_001108520.1  AMSH-like protease

      See identical proteins and their annotated locations for NP_001108520.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241095695..241158225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231297.5 → XP_006231359.1  AMSH-like protease isoform X1

      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    2. XM_006231299.5 → XP_006231361.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006231361.1

      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    3. XM_039091054.2 → XP_038946982.1  AMSH-like protease isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Related
      ENSRNOP00000082601.2, ENSRNOT00000115460.2
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    4. XM_006231296.4 → XP_006231358.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006231358.1

      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    5. XM_039091065.2 → XP_038946993.1  AMSH-like protease isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    6. XM_039091083.2 → XP_038947011.1  AMSH-like protease isoform X3

      Conserved Domains (2) summary
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl13996
      Location:266 → 305
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains

    7. XM_008760346.4 → XP_008758568.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_008758568.1

      UniProtKB/TrEMBL
      A0A8I6AK00, B0BMZ5
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:101 → 186
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain

    8. XM_008760349.4 → XP_008758571.1  AMSH-like protease isoform X2

      See identical proteins and their annotated locations for XP_008758571.1

      UniProtKB/TrEMBL
      A0A8I6AK00
      Related
      ENSRNOP00000066404.2, ENSRNOT00000075598.3
      Conserved Domains (3) summary
      cd08066
      Location:251 → 421
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam03938
      Location:86 → 171
      OmpH; Outer membrane protein (OmpH-like)
      pfam08969
      Location:13 → 114
      USP8_dimer; USP8 dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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