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    Xylt2 xylosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64134, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xylt2provided by RGD
    Official Full Name
    xylosyltransferase 2provided by RGD
    Primary source
    RGD:619765
    See related
    EnsemblRapid:ENSRNOG00000003728 AllianceGenome:RGD:619765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    xylt-II
    Summary
    Predicted to enable magnesium ion binding activity; manganese ion binding activity; and protein xylosyltransferase activity. Predicted to be involved in chondroitin sulfate proteoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within heparin biosynthetic process and proteoglycan biosynthetic process. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in pseudoxanthoma elasticum. Orthologous to human XYLT2 (xylosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 123.0), Spleen (RPKM 93.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Xylt2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80102776..80116346, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79605910..79619482, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82386003..82399485, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene transmembrane protein 92-like Neighboring gene transmembrane protein 92-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC124608

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables manganese ion binding  
    enables manganese ion binding  
    enables manganese ion binding  
    enables protein xylosyltransferase activity  
    enables protein xylosyltransferase activity  
    enables protein xylosyltransferase activity  
    enables protein xylosyltransferase activity  
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    xylosyltransferase 2
    Names
    peptide O-xylosyltransferase 2
    xylosyltransferase II
    NP_071632.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022296.2NP_071632.2  xylosyltransferase 2

      See identical proteins and their annotated locations for NP_071632.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105767
      UniProtKB/Swiss-Prot
      Q9EPI0
      UniProtKB/TrEMBL
      A6HI66, A6HI67, Q3KRD6
      Related
      ENSRNOP00000068532.1, ENSRNOT00000082972.3
      Conserved Domains (2) summary
      pfam02485
      Location:234486
      Branch; Core-2/I-Branching enzyme
      pfam12529
      Location:519698
      Xylo_C; Xylosyltransferase C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      80102776..80116346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005489939.2 RNA Sequence

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