Tbcb tubulin folding cofactor B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tbcbprovided by RGD
Full Name: tubulin folding cofactor Bprovided by RGD
Primary source: RGD:1309965
See related: EnsemblRapid:ENSRNOG00000020781 AllianceGenome:RGD:1309965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZH14; Ckap1
Summary: Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in cytosol. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 230.1), Kidney (RPKM 153.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94605100..94610949, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85477639..85483488, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88680936..88686785, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137061 (e-PCR)
- UniSTS:219150

RH139378 (e-PCR)
- UniSTS:221464

D1Bda12 (e-PCR)
- UniSTS:239759

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-chaperonin tubulin folding pathway	IEA Inferred from Electronic Annotation more info
involved_in tubulin complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tubulin-folding cofactor B

Names: cytoskeleton-associated protein 1; liver cancer related protein; tubulin-folding cofactor B-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040180.1 → NP_001035270.1 tubulin-folding cofactor B

See identical proteins and their annotated locations for NP_001035270.1

Status: PROVISIONAL

Source sequence(s)

AM258961

UniProtKB/TrEMBL

A0JMZ5, Q1RP74, Q1W1V7

Related

ENSRNOP00000028211.4, ENSRNOT00000028211.7

Conserved Domains (2) summary

cd01789
Location:11 → 89

Ubl_TBCB; ubiquitin-like (Ubl) domain found in tubulin-folding cofactor B (TBCB) and similar proteins

pfam01302
Location:161 → 229

CAP_GLY; CAP-Gly domain