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    Atp6v0e2 ATPase, H+ transporting V0 subunit e2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 436582, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp6v0e2provided by RGD
    Official Full Name
    ATPase, H+ transporting V0 subunit e2provided by RGD
    Primary source
    RGD:1303238
    See related
    EnsemblRapid:ENSRNOG00000008218 AllianceGenome:RGD:1303238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NM9.2
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Is active in synaptic vesicle membrane. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 747.6), Kidney (RPKM 500.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp6v0e2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78815771..78818919)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77484868..77488016)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78168117..78171265)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SCO-spondin Neighboring gene uncharacterized LOC120102263 Neighboring gene zinc finger protein 862 Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder 2 Neighboring gene hypothetical LOC100363281 Neighboring gene replication initiator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proton transmembrane transport  
    involved_in synaptic vesicle lumen acidification  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain  

    General protein information

    Preferred Names
    V-type proton ATPase subunit e 2
    Names
    ATPase, H+ transporting, V0 subunit E
    ATPase, H+ transporting, lysosomal V0 subunit E2
    V-ATPase subunit e 2
    vacuolar proton pump subunit e 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002253.1NP_001002253.1  V-type proton ATPase subunit e 2

      See identical proteins and their annotated locations for NP_001002253.1

      Status: VALIDATED

      Source sequence(s)
      CB566985, CB584357, CB757317
      UniProtKB/Swiss-Prot
      Q5EB76
      Related
      ENSRNOP00000010853.3, ENSRNOT00000010853.8
      Conserved Domains (1) summary
      pfam05493
      Location:967
      ATP_synt_H; ATP synthase subunit H

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78815771..78818919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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