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    Tgif1 TGFB-induced factor homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tgif1provided by RGD
    Official Full Name
    TGFB-induced factor homeobox 1provided by RGD
    Primary source
    RGD:1310517
    See related
    EnsemblRapid:ENSRNOG00000015906 AllianceGenome:RGD:1310517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tfig; Tgif
    Summary
    Enables co-SMAD binding activity. Involved in cellular response to growth factor stimulus; negative regulation of gene expression; and response to xenobiotic stimulus. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Biomarker of muscular atrophy. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 114.3), Adrenal (RPKM 93.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tgif1 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118194735..118204354, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (110748094..110757714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119181079..119190698, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene DLG associated protein 1 Neighboring gene uncharacterized LOC102555426 Neighboring gene uncharacterized LOC134480624 Neighboring gene uncharacterized LOC102555570 Neighboring gene uncharacterized LOC120094777 Neighboring gene myosin light chain 12B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC109104, MGC156525

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of amacrine cell differentiation  
    acts_upstream_of cell population proliferation  
    involved_in cellular response to growth factor stimulus PubMed 
    acts_upstream_of_or_within determination of left/right symmetry  
    acts_upstream_of_or_within dorsal/ventral pattern formation  
    acts_upstream_of fibroblast proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression PubMed 
    acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within neural tube closure  
    acts_upstream_of neuron differentiation  
    acts_upstream_of_or_within nodal signaling pathway  
    acts_upstream_of_or_within positive regulation of amacrine cell differentiation  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation  
    acts_upstream_of_or_within regulation of gastrulation  
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within retina development in camera-type eye  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    homeobox protein TGIF1
    Names
    TG interacting factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015020.1 → NP_001015020.1  homeobox protein TGIF1

      See identical proteins and their annotated locations for NP_001015020.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091264
      UniProtKB/TrEMBL
      A0A8I6ACG1, A6KF88, Q5BJZ9
      Related
      ENSRNOP00000021534.5, ENSRNOT00000021534.8
      Conserved Domains (1) summary
      pfam05920
      Location:68 → 107
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      118194735..118204354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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