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    Gldc glycine decarboxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309312, updated on 9-Dec-2024

    Summary

    Symbol
    Gldcprovided by RGD
    Full Name
    glycine decarboxylaseprovided by RGD
    Primary source
    RGD:1308660
    See related
    EnsemblRapid:ENSRNOG00000011599 AllianceGenome:RGD:1308660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables anion binding activity; enzyme binding activity; and glycine dehydrogenase (decarboxylating) activity. Involved in glycine decarboxylation via glycine cleavage system and protein-containing complex assembly. Part of glycine cleavage complex. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 189.6), Kidney (RPKM 170.4) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Gldc in Genome Data Viewer
    Location:
    1q52
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237296753..237375620, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227883249..227962119, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248295140..248377122, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 3 Neighboring gene ubiquitin like with PHD and ring finger domains 2 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4, pseudogene 1 Neighboring gene cytochrome c, somatic, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding PubMed 
    enables glycine binding  
    enables glycine binding PubMed 
    enables glycine dehydrogenase (decarboxylating) activity  
    enables glycine dehydrogenase (decarboxylating) activity PubMed 
    enables glycine dehydrogenase (decarboxylating) activity  
    enables lyase activity  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding PubMed 
    Component Evidence Code Pubs
    part_of glycine cleavage complex  
    part_of glycine cleavage complex PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    glycine dehydrogenase (decarboxylating), mitochondrial
    Names
    glycine decarboxylase, glycine cleavage system protein P)
    glycine dehydrogenase (decarboxylating)
    glycine dehydrogenase (decarboxylating), mitochondrial-like
    glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)
    glycine dehydrogenase [decarboxylating], mitochondrial
    glycine dehydrogenase [decarboxylating], mitochondrial-like
    NP_001402873.1
    XP_006231273.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415944.1NP_001402873.1  glycine dehydrogenase (decarboxylating), mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JUZ5
      Related
      ENSRNOP00000093309.2, ENSRNOT00000110722.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      237296753..237375620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231211.5XP_006231273.1  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUZ5
      Conserved Domains (3) summary
      PRK05367
      Location:61823
      PRK05367; glycine dehydrogenase; Provisional
      pfam02347
      Location:69492
      GDC-P; Glycine cleavage system P-protein
      cl18945
      Location:522837
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

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