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    Cdh10 cadherin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29181, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdh10provided by RGD
    Official Full Name
    cadherin 10provided by RGD
    Primary source
    RGD:619741
    See related
    EnsemblRapid:ENSRNOG00000009771 AllianceGenome:RGD:619741
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Orthologous to human CDH10 (cadherin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 120.0) See more
    Orthologs
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    Genomic context

    See Cdh10 in Genome Data Viewer
    Location:
    2q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (70355521..70577880)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (68628623..68850995)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (69415174..69636849)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein crumbs homolog 3-like Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC120100745 Neighboring gene uncharacterized LOC120100746 Neighboring gene RB binding protein 9, serine hydrolase, pseudogene 1 Neighboring gene uncharacterized LOC102553625 Neighboring gene uncharacterized LOC102553734 Neighboring gene uncharacterized LOC120100560

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding  
    enables cadherin binding  
    enables calcium ion binding  
    Process Evidence Code Pubs
    involved_in adherens junction organization  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in cell migration  
    involved_in cell morphogenesis  
    involved_in cell-cell adhesion PubMed 
    involved_in cell-cell adhesion mediated by cadherin  
    involved_in cell-cell junction assembly  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in synaptic membrane adhesion  
    involved_in synaptic membrane adhesion  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in adherens junction  
    part_of catenin complex  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in postsynaptic specialization membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 
    is_active_in synapse  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168631.1NP_001162102.1  cadherin-10 precursor

      See identical proteins and their annotated locations for NP_001162102.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6JMU7, F1LR98
      Conserved Domains (3) summary
      cd11304
      Location:164265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80158
      CA; Cadherin repeats
      pfam01049
      Location:643780
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      70355521..70577880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232080.5XP_006232142.1  cadherin-10 isoform X2

      UniProtKB/TrEMBL
      A6JMU7
      Related
      ENSRNOP00000013152.2, ENSRNOT00000013152.6
      Conserved Domains (3) summary
      cd11304
      Location:164265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80158
      CA; Cadherin repeats
      pfam01049
      Location:641778
      Cadherin_C; Cadherin cytoplasmic region
    2. XM_006232079.5XP_006232141.1  cadherin-10 isoform X1

      See identical proteins and their annotated locations for XP_006232141.1

      UniProtKB/TrEMBL
      A6JMU7, F1LR98
      Conserved Domains (3) summary
      cd11304
      Location:164265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80158
      CA; Cadherin repeats
      pfam01049
      Location:643780
      Cadherin_C; Cadherin cytoplasmic region
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