Pum2 pumilio RNA-binding family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pum2provided by RGD
Official Full Name: pumilio RNA-binding family member 2provided by RGD
Primary source: RGD:1311024
See related: EnsemblRapid:ENSRNOG00000006180 AllianceGenome:RGD:1311024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Involved in several processes, including positive regulation of sprouting of injured axon; regulation of gene expression; and regulation of postsynapse assembly. Located in neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 341.7), Spleen (RPKM 285.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (37182130..37262223)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (31462879..31542976)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (33786184..33865693)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-495-3p promotes cardiac hypertrophy by targeting Pum2.
Title: MiR-495-3p promotes cardiac hypertrophy by targeting Pum2.
Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
Title: Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
Title: Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
These results reveal that Pum2 shapes axonal transcriptomes by preventing the transport of Pumilio-binding elements -containing mRNAs into axons
Title: Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body.
Pumilio-2 is central to the homeostatic mechanism regulating membrane excitability in visual cortex pyramidal neurons.
Title: Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.
Pumilio 2 regulates dendrite morphogenesis and synaptic function.
Title: Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function.
Mef2-induced expression of at least three individual miRNAs of the miR379-410 cluster is required for activity-dependent dendritic outgrowth of hippocampal neurons.
Title: Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.

Submit: New GeneRIF Correction

General gene information

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Markers

Pum2 (e-PCR), detects polymorphism
- UniSTS:479021

RH141048 (e-PCR)
- UniSTS:223048

D6Got27 (e-PCR)
- UniSTS:113642

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables pumilio-response element binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pumilio homolog 2

Names: pumilio 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106715.1 → NP_001100185.1 pumilio homolog 2 isoform 14

See identical proteins and their annotated locations for NP_001100185.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A0A8I6AD36, A6HAM2, D3ZQL8

Related

ENSRNOP00000008359.5, ENSRNOT00000008359.8

Conserved Domains (1) summary

cd07920
Location:718 → 1039

Pumilio; Pumilio-family RNA binding domain
NM_001434230.1 → NP_001421159.1 pumilio homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K8F9, A0A8I6AD36
NM_001434231.1 → NP_001421160.1 pumilio homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434232.1 → NP_001421161.1 pumilio homolog 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434233.1 → NP_001421162.1 pumilio homolog 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434234.1 → NP_001421163.1 pumilio homolog 2 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434235.1 → NP_001421164.1 pumilio homolog 2 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434236.1 → NP_001421165.1 pumilio homolog 2 isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434237.1 → NP_001421166.1 pumilio homolog 2 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434238.1 → NP_001421167.1 pumilio homolog 2 isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZSK1, A0A8I6AD36
NM_001434239.1 → NP_001421168.1 pumilio homolog 2 isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434240.1 → NP_001421169.1 pumilio homolog 2 isoform 11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434241.1 → NP_001421170.1 pumilio homolog 2 isoform 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36
NM_001434242.1 → NP_001421171.1 pumilio homolog 2 isoform 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AD36

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

37182130..37262223

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239879.5 → XP_006239941.1 pumilio homolog 2 isoform X1

Conserved Domains (1) summary

cd07920
Location:722 → 1045

Pumilio; Pumilio-family RNA binding domain
XM_006239880.5 → XP_006239942.1 pumilio homolog 2 isoform X8

Related

ENSRNOP00000074592.3, ENSRNOT00000082598.3

Conserved Domains (1) summary

cd07920
Location:722 → 1043

Pumilio; Pumilio-family RNA binding domain
XM_017594073.3 → XP_017449562.1 pumilio homolog 2 isoform X10

Conserved Domains (1) summary

cd07920
Location:643 → 966

Pumilio; Pumilio-family RNA binding domain
XM_006239883.5 → XP_006239945.1 pumilio homolog 2 isoform X15

Related

ENSRNOP00000107432.1, ENSRNOT00000161902.1

Conserved Domains (1) summary

cd07920
Location:643 → 964

Pumilio; Pumilio-family RNA binding domain
XM_039111924.2 → XP_038967852.1 pumilio homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AD36

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
XM_039111925.2 → XP_038967853.1 pumilio homolog 2 isoform X3

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain
XM_039111936.2 → XP_038967864.1 pumilio homolog 2 isoform X11

Conserved Domains (1) summary

cd07920
Location:642 → 965

Pumilio; Pumilio-family RNA binding domain
XM_039111938.2 → XP_038967866.1 pumilio homolog 2 isoform X12

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
XM_039111928.2 → XP_038967856.1 pumilio homolog 2 isoform X4
XM_063261634.1 → XP_063117704.1 pumilio homolog 2 isoform X6
XM_039111939.2 → XP_038967867.1 pumilio homolog 2 isoform X13

Conserved Domains (1) summary

cd07920
Location:638 → 959

Pumilio; Pumilio-family RNA binding domain
XM_039111930.2 → XP_038967858.1 pumilio homolog 2 isoform X5

UniProtKB/TrEMBL

A0A8I6AD36

Conserved Domains (1) summary

cd07920
Location:716 → 1039

Pumilio; Pumilio-family RNA binding domain
XM_039111931.2 → XP_038967859.1 pumilio homolog 2 isoform X7

Conserved Domains (1) summary

cd07920
Location:716 → 1037

Pumilio; Pumilio-family RNA binding domain
XM_063261638.1 → XP_063117708.1 pumilio homolog 2 isoform X14
XM_063261642.1 → XP_063117712.1 pumilio homolog 2 isoform X16
XM_063261636.1 → XP_063117706.1 pumilio homolog 2 isoform X9

UniProtKB/TrEMBL

A0A8I6AD36

Related

ENSRNOP00000081323.2, ENSRNOT00000108134.2
XM_063261637.1 → XP_063117707.1 pumilio homolog 2 isoform X9

UniProtKB/TrEMBL

A0A8I6AD36
XM_063261633.1 → XP_063117703.1 pumilio homolog 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K8F9, A0A8I6AD36
XM_063261635.1 → XP_063117705.1 pumilio homolog 2 isoform X8

UniProtKB/TrEMBL

A0A8I6AD36
XM_063261639.1 → XP_063117709.1 pumilio homolog 2 isoform X10
XM_063261641.1 → XP_063117711.1 pumilio homolog 2 isoform X15

UniProtKB/TrEMBL

A0A8I5ZSK1, A0A8I6AD36
XM_063261640.1 → XP_063117710.1 pumilio homolog 2 isoform X11
XM_063261643.1 → XP_063117713.1 pumilio homolog 2 isoform X17
XM_063261644.1 → XP_063117714.1 pumilio homolog 2 isoform X18