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    Laptm5 lysosomal protein transmembrane 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89783, updated on 9-Dec-2024

    Summary

    Official Symbol
    Laptm5provided by RGD
    Official Full Name
    lysosomal protein transmembrane 5provided by RGD
    Primary source
    RGD:621838
    See related
    EnsemblRapid:ENSRNOG00000011054 AllianceGenome:RGD:621838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    gcd-10
    Summary
    Predicted to enable protein sequestering activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lysosomal transport; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in lysosome. Orthologous to human LAPTM5 (lysosomal protein transmembrane 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 777.4), Spleen (RPKM 732.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Laptm5 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (148371880..148393927)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (143087759..143109807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (149015793..149069719)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479034 Neighboring gene matrilin 1 Neighboring gene uncharacterized LOC134487086

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding  
    enables protein sequestering activity  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor  
    involved_in defense response to tumor cell  
    involved_in induction of programmed cell death  
    involved_in intracellular protein transport  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in negative regulation of B cell activation  
    involved_in negative regulation of T cell activation  
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in negative regulation of activated T cell proliferation  
    involved_in negative regulation of autophagic cell death  
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of pre-B cell receptor expression  
    involved_in negative regulation of type II interferon production  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of lysosomal membrane permeability  
    involved_in positive regulation of macrophage cytokine production  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of proteolysis involved in protein catabolic process  
    involved_in positive regulation of receptor catabolic process  
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process  
    involved_in protein localization to lysosome  
    involved_in protein targeting to lysosome  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle  
    located_in cytosol  
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome PubMed 
    located_in lysosome  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    part_of protein-containing complex  
    located_in transport vesicle  

    General protein information

    Preferred Names
    lysosomal-associated transmembrane protein 5
    Names
    granule cell death-10
    lysosomal multispanning membrane protein 5
    lysosomal-associated protein transmembrane 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053538.2 → NP_445990.2  lysosomal-associated transmembrane protein 5

      See identical proteins and their annotated locations for NP_445990.2

      Status: PROVISIONAL

      Source sequence(s)
      BC060517
      UniProtKB/TrEMBL
      A0A9K3Y751, F1LN25, Q6P9Z7, Q9JJ55
      Related
      ENSRNOP00000071739.2, ENSRNOT00000083028.3
      Conserved Domains (1) summary
      TIGR00799
      Location:4 → 261
      mtp; Golgi 4-transmembrane spanning transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      148371880..148393927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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