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    Osgepl1 O-sialoglycoprotein endopeptidase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osgepl1provided by RGD
    Official Full Name
    O-sialoglycoprotein endopeptidase-like 1provided by RGD
    Primary source
    RGD:1305575
    See related
    EnsemblRapid:ENSRNOG00000004001 AllianceGenome:RGD:1305575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be active in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 97.1), Muscle (RPKM 96.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osgepl1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (55707389..55725325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48214995..48229440, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53084042..53098029, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 40 member 1 Neighboring gene proteolipid protein 2 like 1 Neighboring gene ASNSD1 upstream open reading frame Neighboring gene asparagine synthetase domain containing 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene large ribosomal subunit protein eL37-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
    Names
    N6-L-threonylcarbamoyladenine synthase
    O-sialoglycoprotein endopeptidase-like protein 1
    probable O-sialoglycoprotein endopeptidase 2
    probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
    probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
    t(6)A synthase
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
    tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
    NP_001380997.1
    NP_001380999.1
    XP_038939388.1
    XP_063123126.1
    XP_063123127.1
    XP_063123128.1
    XP_063123129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394068.1 → NP_001380997.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q4V7F3
      UniProtKB/TrEMBL
      A6INU3, Q6AYN7
      Related
      ENSRNOP00000005408.4, ENSRNOT00000005408.7
      Conserved Domains (1) summary
      TIGR03723
      Location:39 → 372
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

    2. NM_001394070.1 → NP_001380999.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q4V7F3
      UniProtKB/TrEMBL
      A6INU3, Q6AYN7
      Conserved Domains (1) summary
      TIGR03723
      Location:39 → 372
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

    RNA

    1. NR_172073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      55707389..55725325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267059.1 → XP_063123129.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q4V7F3
      UniProtKB/TrEMBL
      A6INU3, Q6AYN7

    2. XM_039083460.2 → XP_038939388.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X4

      Conserved Domains (1) summary
      TIGR03723
      Location:39 → 329
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD

    3. XM_063267057.1 → XP_063123127.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7X8, Q6AYN7

    4. XM_063267058.1 → XP_063123128.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q6AYN7

    5. XM_063267056.1 → XP_063123126.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7X8, Q6AYN7
      Related
      ENSRNOP00000077826.1, ENSRNOT00000107507.2

    RNA

    1. XR_010054587.1 RNA Sequence

    2. XR_357008.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7F3.1 GenPept UniProtKB/Swiss-Prot:Q4V7F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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