Hcst hematopoietic cell signal transducer [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hcstprovided by RGD
Official Full Name: hematopoietic cell signal transducerprovided by RGD
Primary source: RGD:1359238
See related: EnsemblRapid:ENSRNOG00000020849 AllianceGenome:RGD:1359238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dap10
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein phosphorylation. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human HCST (hematopoietic cell signal transducer). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 41.5), Thymus (RPKM 34.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94804429..94806661, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85676976..85679083, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88879425..88881653, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both adaptor proteins DAP12 and DAP10 can associate with rat CD94/NKG2C; rat CD94 coimmunoprecipitates with both DAP12 and DAP10.
Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hematopoietic cell signal transducer

Names: DNAX-activation protein 10; membrane protein DAP10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005900.1 → NP_001005900.1 hematopoietic cell signal transducer precursor

See identical proteins and their annotated locations for NP_001005900.1

Status: PROVISIONAL

Source sequence(s)

AY247020

UniProtKB/Swiss-Prot

Q6X9T8

UniProtKB/TrEMBL

A0A8I5Y9X6, A6J9X2

Related

ENSRNOP00000028287.4, ENSRNOT00000028287.6

Conserved Domains (1) summary

pfam07213
Location:1 → 79

DAP10; DAP10 membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

94804429..94806661 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228785.5 → XP_006228847.1 hematopoietic cell signal transducer isoform X1

UniProtKB/TrEMBL

A6J9X1

Conserved Domains (1) summary

pfam07213
Location:1 → 78

DAP10; DAP10 membrane protein