Kbtbd3 kelch repeat and BTB domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kbtbd3provided by RGD
Official Full Name: kelch repeat and BTB domain containing 3provided by RGD
Primary source: RGD:1310895
See related: EnsemblRapid:ENSRNOG00000069206 AllianceGenome:RGD:1310895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD3 (kelch repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 45.4), Kidney (RPKM 43.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (9749229..9780036)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (1464162..1491144)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (1450345..1477250)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kelch repeat and BTB domain-containing protein 3

Names: kelch repeat and BTB (POZ) domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108121.2 → NP_001101591.1 kelch repeat and BTB domain-containing protein 3

See identical proteins and their annotated locations for NP_001101591.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6KQJ4, D4A7F5

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
NM_001433311.1 → NP_001420240.1 kelch repeat and BTB domain-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6KQJ4, D4A7F5
NM_001433312.1 → NP_001420241.1 kelch repeat and BTB domain-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6KQJ4, D4A7F5
NM_001433313.1 → NP_001420242.1 kelch repeat and BTB domain-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6KQJ4, D4A7F5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

9749229..9780036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242474.5 → XP_006242536.1 kelch repeat and BTB domain-containing protein 3 isoform X1

Related

ENSRNOP00000085465.1, ENSRNOT00000120313.2

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
XM_006242478.5 → XP_006242540.1 kelch repeat and BTB domain-containing protein 3 isoform X2

Conserved Domains (6) summary

smart00612
Location:325 → 375

Kelch; Kelch domain

PHA03098
Location:16 → 520

PHA03098; kelch-like protein; Provisional

sd00038
Location:255 → 310

Kelch; KELCH repeat [structural motif]

pfam00651
Location:1 → 67

BTB; BTB/POZ domain

pfam01344
Location:464 → 507

Kelch_1; Kelch motif

pfam07707
Location:75 → 176

BACK; BTB And C-terminal Kelch
XM_006242477.5 → XP_006242539.1 kelch repeat and BTB domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006242539.1

UniProtKB/TrEMBL

A6KQJ4, D4A7F5

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
XM_006242476.4 → XP_006242538.1 kelch repeat and BTB domain-containing protein 3 isoform X1

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
XM_039081335.2 → XP_038937263.1 kelch repeat and BTB domain-containing protein 3 isoform X1

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
XM_039081336.2 → XP_038937264.1 kelch repeat and BTB domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A6KQJ4, D4A7F5

Conserved Domains (3) summary

PHA03098
Location:38 → 595

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 385

Kelch; KELCH repeat [structural motif]

cd18271
Location:24 → 153

BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)