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    Stard4 StAR-related lipid transfer domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291699, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stard4provided by RGD
    Official Full Name
    StAR-related lipid transfer domain containing 4provided by RGD
    Primary source
    RGD:1309475
    See related
    EnsemblRapid:ENSRNOG00000020468 AllianceGenome:RGD:1309475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cholesterol transport and positive regulation of steroid metabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol and endoplasmic reticulum. Orthologous to human STARD4 (StAR related lipid transfer domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 143.5), Thymus (RPKM 118.0) and 9 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Stard4 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (25088831..25104172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (24814683..24830024, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (25982210..25997555, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482925 Neighboring gene uncharacterized LOC102549443 Neighboring gene neuronal regeneration related protein

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol transport involved in cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol transport involved in cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    stAR-related lipid transfer protein 4
    Names
    StAR-related lipid transfer (START) domain containing 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106159.2NP_001099629.1  stAR-related lipid transfer protein 4

      See identical proteins and their annotated locations for NP_001099629.1

      Status: VALIDATED

      Source sequence(s)
      CB547156, JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J2R7, D3Z9I9
      Related
      ENSRNOP00000027755.4, ENSRNOT00000027755.8
      Conserved Domains (1) summary
      cl14643
      Location:21222
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      25088831..25104172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600918.3XP_017456407.1  stAR-related lipid transfer protein 4 isoform X1