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    Prss30 protease, serine, 30 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287106, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss30provided by RGD
    Official Full Name
    protease, serine, 30provided by RGD
    Primary source
    RGD:735142
    See related
    EnsemblRapid:ENSRNOG00000033266 AllianceGenome:RGD:735142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    tmsp-1; Tmprss8
    Summary
    Enables serine-type endopeptidase activity and sodium channel regulator activity. Involved in proteolysis and sodium ion transport. Predicted to be located in side of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 54.5), Uterus (RPKM 18.3) and 1 other tissue See more
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    Genomic context

    See Prss30 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13511916..13519968, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13007341..13014827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13348289..13355833, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene uncharacterized LOC120095045 Neighboring gene zymogen granule protein 16B Neighboring gene serine protease 22 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine protease 30
    Names
    distal intestinal serine protease
    transmembrane protease, serine 8 (intestinal)
    transmembrane serine protease 1
    transmembrane serine protease 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199371.2NP_955403.2  serine protease 30 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P83748
      Related
      ENSRNOP00000037368.5, ENSRNOT00000034340.7
      Conserved Domains (1) summary
      cd00190
      Location:31269
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13511916..13519968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245923.5XP_006245985.1  serine protease 30 isoform X1

      See identical proteins and their annotated locations for XP_006245985.1

      UniProtKB/Swiss-Prot
      P83748
      Conserved Domains (1) summary
      cd00190
      Location:31269
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_063268554.1XP_063124624.1  serine protease 30 isoform X2

      UniProtKB/TrEMBL
      A6HCP4, F1LQU8
    3. XM_063268555.1XP_063124625.1  serine protease 30 isoform X2

      UniProtKB/TrEMBL
      A6HCP4, F1LQU8
    4. XM_063268553.1XP_063124623.1  serine protease 30 isoform X1

      UniProtKB/Swiss-Prot
      P83748
    5. XM_063268551.1XP_063124621.1  serine protease 30 isoform X1

      UniProtKB/Swiss-Prot
      P83748